Inclusion complexes with silybinin, their preparation and pharma

Details Inclusion complexes with silybinin, their preparation and pharma Inclusion complexes with silybinin, their preparation and pharma

1990-10-09

1993-03-30

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536103, A61K 31685, A61K 3170, C08B 3716

Patent

active

051984300

ABSTRACT:
The invention relates to inclusion complexes of Silybinin with a cyclodextrin selected from the group consisting of .alpha.-, .beta.- and .gamma.-cyclodextrin and a suitable derivative thereof and to the method for the preparation thereof. The inclusion complexes of Silybinin showed a highly improved bioavailability in comparison to Silybinin which makes them particularly interesting in the treatment of various hepatotoxic conditions.

REFERENCES:
patent: 4727064 (1988-02-01), Pitha
patent: 4826963 (1989-05-01), Stadler nee Szoke et al.
patent: 4834985 (1989-05-01), Elger et al.
patent: 4869904 (1989-09-01), Uekama et al.
Chem. Pharm. Bull., No. 4, 1983, pp. 1350-1356; H. Sekikawa et al.: "Dissolution Behavior and Gastrointestinal Absorption of Dicumarol from Solid Dispersion Systems of Dicmarol-Polyvinylpyrrolidone and Dicumarol-.beta.-Cyclodextrin".
Szejtli, "Cyclodextrin Technology", Kluwer Academic Publishers, London, England, 1988, p. 84.

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