Inclusion complexes of dipyridamole with cyclodextrins

Details Inclusion complexes of dipyridamole with cyclodextrins Inclusion complexes of dipyridamole with cyclodextrins

1988-06-01

1991-04-23

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514258, 536103, A01N 4340, A61K 31715, C08B 3716

Patent

active

050100645

ABSTRACT:
Inclusion complexes of dipyridamole with beta cyclodextrins in the molar ratio of dipyridamole to cyclodextrin ranging from 1:1 to 1:12 provides higher and more consistent blood concentrations than can be achieved by the dipyridamole alone.

REFERENCES:
patent: 4054736 (1977-10-01), Hayashi et al.
patent: 4228160 (1980-10-01), Szejtli et al.
patent: 4438106 (1984-03-01), Wagu et al.
patent: 4518588 (1985-05-01), Szejtli et al.
patent: 4565807 (1986-01-01), Uekama et al.
patent: 4603123 (1986-07-01), Chiesi et al.
Kaneto Uekama: Inclusion Complexes of Cyclodextrins With Organic Drug Molecules (The Japanese Journal of Antiobiotics-Dec. 1979, pp. 103-110).
G. E. Hardee et al., Microcalorimetric Investigations of Pharmaceutical Complexes (Acta Pharm. Suec. 15, 188-199 (1978).
J. Pitha et al, "Hydroxypropyl-.beta.-Cyclodextrin: Preparation and Characterization; Effects on Solubility of Drugs," International Journal of Pharmaceutics, vol. 29 (Mar., 1986), pp. 73-82.

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