Inclusion complex of Rifampicin, an anti-tubercular drug,...

Details Inclusion complex of Rifampicin, an anti-tubercular drug,... Inclusion complex of Rifampicin, an anti-tubercular drug,...

2006-02-21

2006-02-21

Wilson, James O. (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S060000, C514S338000, C514S026000, C536S103000, C536S120000, C536S122000, C536S046000, C424S093200, C435S473000

Reexamination Certificate

active

07001893

ABSTRACT:
The present invention relates to an inclusion complex of Rifampicin and cyclodextrin (CD) that can be used as an anti-tubercular drug. The present invention also relates to a process for synthesizing inclusion complexes of the anti-tubercular drug, Rifampicin, with β-CD (β-cyclodextrin) and HP-β-CD (2-hydroxy propyl cyclodextrin) and characterization of these inclusion complexes.

REFERENCES:
patent: 5134127 (1992-07-01), Stella et al.
patent: 6495160 (2002-12-01), Esposito et al.
patent: 6500463 (2002-12-01), van Lengerich
patent: 1080528 (1994-01-01), None
Kuchekar et al. “Solid dispersions of rifampicin.” Abstract: Eastern Pharmacist, 1998, 41(492), 133-134.
Singh, Saranjit, “Study on poor bioavailability of rifampicin in FDCs for anti-TB therapy,” NIPER-Chronicle Pharmabiz, Dec. 20, 2001, p. 28.
Kuchekar et al., “Solid Dispersions of Rifampicin,” The Eastern Pharmacist, 1998, pp. 133-143.

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