Inbred miniature swine and uses thereof

Details Inbred miniature swine and uses thereof Inbred miniature swine and uses thereof

2006-11-28

2006-11-28

Nguyen, Dave Trong (Department: 1632)

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

C800S008000

Reexamination Certificate

active

07141716

ABSTRACT:
The invention provides a swine which is homozygous for a major histocompatibility complex haplotype and at least 60% homozygous at all other genetic loci and such animal is propagatable, and a cell or an organ derived therefrom. The invention also provides a method for providing a swine which is homozygous at swine leukocyte antigens (SLA) A, B, C, DR, and DQ, and in which at least 60% of all other genetic loci are homozygous, as well as a method of inducing tolerance in a recipient mammal of a first species to a graft from a donor mammal of a second species.

REFERENCES:
patent: WO 94/26289 (1994-11-01), None
patent: WO 95/13363 (1995-05-01), None
patent: WO 97/06241 (1997-02-01), None
patent: WO 97/41863 (1997-11-01), None
Wolf E, Nuclear transfer in mammals: recent developments and future perspectives, 1998, J of Biotechnology, 65, 99-110.
Prather RS, Development of the techniques for nuclear transfer in pigs, 1999, Theriogenology, 51, 487-498.
Prather RS, Nuclear transplantation in early pig embryos, 1989, Biology of Reproduction, 41, 414-418.
Mollnes TE, Xenotransplantation: how to overcome the complement obstable?, 1999, Molecular Immunology, 36, 269-276.
Brouard S, T cell response in xenorecognition and xenografts: a review, 1999, 60, 455-468.
Lambrigts D, Discordant organ xenotransplantation in primates, 1998, Transplantation, 66, 547-561.
Sachs D, Swine as models in biomedical research, Seventh Charles River International Symposium, Mar. 15, 1992.
Lambrigts D et al. Transplantation 66:547-561, 1998.
Brourard S et al. Human Immunology 60:455-468, 1999.
Mollness TE and Fiane AE. Molecular Immunology 36:269-276, 1999.
Seidel GE. J. Anim. Sci. 71(Suppl. 3): 26-33, 1993.
Cameron ER. Molecular Biotechnology 7:253-265, 1997.
Mullins JJ et al. Hypertension 22:630-633, 1993.
Kuhholzer B et al. Proceedings of the Society for Experimental Biology and Medicine 224:240-245, 2000.
Wolf E. et al. Journal of Biotechnology 65: 99-110, 1998.
Moreadith and Radford (J. Mol. Med. 75:208-216, 1997).
Seamark, Reprod. Fertil. Dev. 6: 653-657, 1994.
Mullins LJ and Mullins JJ. J. Clin. Invest.97:1557-1560, 1996.
Gardner RL and Brook FA International J. of Dev. Biol. 41:235-243, 1997.
Chapter 18 in Genetics by George P. Redei, McMillan Publishing Co., Inc., NY, 1982.
K. Christensen et al., “A note on effect of inbreeding on production traits in pigs”, Anim. Prod., 1994, vol. 58, p. 298-300.
K. Christensen et al., “Joint effect of 21 marker loci and effect of realized inbreeding on growth in pigs”, Animal Science, 1996, vol. 62, p. 541-546.
M. Fredholm et al., “Characterization of 24 porcine (dA-dC)n-(dT-dG)nmicrosatellites: genotyping of unrelated animals from four breeds and linkage studies”, Mammalian Genome 1993, vol. 4 p. 187-192.
W J. Hawthorne et al., “Characterisation of an Inbred Pig Colony”, Sixteenth Sci. Meeting, Program and Abstracts for the Australian Academy of Sciences, (htt p: 11 www.medeserv. com. au/racp/tsanz/ t sm653c.htm) Apr. 1998, Abstract # 25.
Sachs, David, “MHC-Homozygous Miniature Swine”, Swindle, M.M. (Ed.).Swine as Models in Biomedical Research, Seventh Charles River International Symposium, Danvers, MA, 1992, pp. 3-15, XP000856305.
Yamada, K. et al., “Human anti-pig T-cell mediated cytotoxicity”Xenotransplantation, vol. 3, No. 2, May 1996, pp. 179-187, XP000856210.
Rosengard, B.R. et al., “Selective Breeding of Miniature Swine Leads To An Increased Rate Of Acceptance Of MHC-Identical, But Not Of Class I-Disparate, Renal Allografts”,Journal Of Immunology, vol. 149, No. 3, 1992, pp. 1099-1103, XP002123608.
Brouard et al.,Human Immunology60:455-468 (1999).
Cameron,Molecular Biotechnology7:253-265 (1997).
Chapter 18 in Genetics by George P. Redei, McMillan Publishing Co., Inc., NY (1982).
Gardner et al.,International J. Dev. Biol. 41:235-243 (1997).
Kuhholzer et al.,Proceedings of the Society for Experimental Biology and Medicine224:240-245 (2000).
Lambrigts et al.,Transplantation66:547-561 (1998).
Mollness et al.,Molecular Immunology36:269-276 (1999).
Moreadith et al.,J. Mol. Med. 75:208-216 (1997).
Mullins et al.,Hypertension22:630-633 (1993).
Mullins et al.,J. Clin. Invest. 97:1557-1560 (1996).
Seamark,Reprod. Fertil. Dev. 6:653-657 (1994).
Seidel,J. Anim. Sci. 71(3):26-33 (1993).
Wolf et al.,J. Biotechnology65:99-110 (1998).

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