Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-09-04
2000-12-19
McKane, Joseph K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514465, 514506, 514532, 514569, 546348, 546339, 546346, 549440, 549366, 560 21, 560100, 562488, 562490, A61K 3136, A61K 3144, C07D21100, C07D21302
Patent
active
061628107
ABSTRACT:
A new family of inadone and tetralone tubulin-binding compounds (TBs) is disclosed. Unlike classical TBs, which inhibit mitosis among affected dividing cells, the TBs of the invention possess two unique properties: (1) they induce apoptosis among stationary phase (non-dividing) malignant cells, yet do not impair the viability of normal nonproliferating cells; and, (2) they affect cells which have acquired MDR more powerfully than they affect cells without MDR. Thus, the TBs of the invention provide means to target malignant cells for chemotherapy, even after previous therapies have failed, without affecting normal cells and tissues in the host.
REFERENCES:
patent: 3843665 (1974-10-01), Coombs et al.
patent: 4162162 (1979-07-01), Dueber
Bahner, Carl, et al., "Benzylideneindenes with Oxygen Attached to the Indene Ring," J. Med. Chem. (1969) vol. 12, No. 4, 721-2.
Henin, Jacques, et al., Hexahydro-5, 6, 6a, 7, 12, 14 isoquino[2,3-b] benzazepine-2. Novel Access. J. Heterocycl. Chem. (1986) vol. 23, No. 4, 975-9.
Gupta, Rajive, et al., "Improved Microwave-induced Synthesis of Chalcones and Related Enones." Indian J. Chem., Sect. B, Org. Chem. Incl. Med. Chem. (1995) vol. 34B(1), 61-2. (Abstract).
Ghannoum et al., Microbios. (1989), 60(242), 23-33.
Levai et al., Pharmazie. (1992), 47(1), 56-7.
Bloxham et al., J. Chem. Soc. Perkin Trans. (1993), 24, 3055-9.
Sergejew et al., J. Enzyme Inhibition, (1994), 8 113-122.
Fies et al., J. Prakt. Chem., (1995), 337, 596-8.
Lankin et al. J. Heterocycl. Chem., (1973) 10(6), 1035-8.
Henin et al. J. Heterocycl. Chem., (1986) 23, 975-9.
Kuck et al. Chem. Ber., (1987) 120, 589-95.
Vavache-Beranger et al. Farmaco-Ed. Sc., (1987) 42(6), 465-73.
Carson Dennis A.
Cottam Howard B.
Leoni Lorenzo
Shih Hsien C.
McKane Joseph K.
Solola Taofiq A.
The Regents of the University of California
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