Inactivation of viruses in labile blood derivatives

Details Inactivation of viruses in labile blood derivatives Inactivation of viruses in labile blood derivatives

1984-12-21

1986-09-23

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Lymphokine

424 86, 424101, 424 88, A61K 3918, A61K 3929

Patent

active

046135014

ABSTRACT:
There is disclosed a process for obtaining a protein-containing composition which is substantially free of lipid-containing viruses without incurring substantial protein denaturation comprising contacting said protein-containing composition with an effective amount of oleic acid, its ester or alkali or alkaline earth metal salt for a sufficient period of time to inactivate virus contained therein.

REFERENCES:
patent: 3962421 (1976-06-01), Neurath
patent: 4314997 (1982-02-01), Shanbrom
patent: 4315919 (1982-02-01), Shanbrom
patent: 4370264 (1983-01-01), Kotitschke et al.
patent: 4412985 (1983-11-01), Shanbrom
patent: 4481189 (1984-11-01), Prince
patent: 4540573 (1985-09-01), Neurath et al.
Arch. Virology, 66, 301-307 (1980), Kohn et al.
J. Exp. Med., 71, 661-681 (1940), Stock et al.

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