Inactivation of viruses in cell- and protein-containing composit

Details Inactivation of viruses in cell- and protein-containing composit Inactivation of viruses in cell- and protein-containing composit

1988-12-02

1991-10-08

Rosen, Sam

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

435 1, 435 2, 514 2, 424529, 424530, 424531, 424583, A61K 31335

Patent

active

050554859

ABSTRACT:
A process of inactivating infectious viruses in a cell-containing or a protein-containing composition containing such viruses, comprising contacting such composition with an effective amount of at least one aryl diol epoxide of the formula ##STR1## in which X is an aromatic ring system having from 3 to 6 used rings,
for a sufficient period of time substantially to inactivate said viruses without incurring substantial disruption or inactivation of cells or without incurring substantial protein denaturation.

REFERENCES:
Yagi et al. J. Am. Ch. Soc. vol. 99(1977) pp. 1604-1611.
Wislocki et al.--Cancer Research vol. 36 Sep. 1976 pp. 3350-3357.
Wood et al.--Cancer Research vol. 36 (Sep. 1976) pp. 3358-3366.

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