Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1994-06-03
1996-09-17
Zitomer, Stephanie W.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435 5, 435 6, 435 911, 435 912, 435 691, 4351731, 4351733, 435810, 422 50, 422 681, 422186, 4221863, 436501, 436 63, 536 221, 536 231, 935 77, 935 78, 935 88, C07H 2100
Patent
active
055569587
ABSTRACT:
The present invention contemplates methods of decontaminating human fluids prior to processing in the clinical laboratory. The techniques handle large volumes of human serum without impairing the testing results. Novel compounds for photodecontaminating biological material are also contemplated which are compatible with clinical testing, in that they do not interfere with serum analytes.
REFERENCES:
patent: 4124598 (1978-11-01), Hearst et al.
patent: 4169204 (1979-09-01), Hearst et al.
patent: 4196281 (1980-04-01), Hearst et al.
patent: 4727027 (1988-02-01), Wiesehahn et al.
patent: 4748120 (1988-05-01), Wiesehahn
Dodd et al. (1991) Transfusion, vol. 31, No. 6, pp. 483-490.
Hanson (1992) Blood Cells, vol. 18, pp. 7-25.
Lee et al. (1988) Nuc. Acids Res., vol. 16, No. 22, pp. 10681-10697.
Resnick, et al., "Stability and Inactivation of HTLV-III/LAV Under Clinical and Laboratory Environments," JAMA 255:1887 (1986).
G. D. Cimino, et al., "Psoralens as Photoactive Probes of Nucleic Acid Structure and Function: Organic Chemistry, Photochemistry, and Biochemistry," Ann. Rev. Biochem. 54:1151 (1985).
Hearst et al., "The reaction of the psoralens with deoxyribonucleic acid," Quart. Rev. Biophys. 17:1 (1984).
S. I. Isaacs et al., "Synthesis and Characterization of New Psoralen Derivatives with Superior Photoreactivity with DNA and RNA," Biochemistry 16:1058 (1977).
S. T. Isaacs et al., "A Photochemical Characterization of Reactions of Psoralen Derivatives with DNA," Trends in Photobiology (Plenum) pp. 279-294 (1982).
J. Tessman et al., "Photochemistry of the Furan-Side 8-Methoxypsoralen-Thymidine Monoadduct Inside the DNA Helix. Conversion to Diadduct and to Pyrone-Side Monoadduct," Biochem. 24:1669 (1985).
H. J. Alter et al., "Photochemical Decontamination of Blood Components Containing Hepatitis B and non-A, Non-B Virus," The Lancet pp. 1446-1450 (Dec. 24/31, 1988).
L. Lin, et al., "Use of 8-Methoxypsoralen and Long-Wavelength Ultraviolet Radiation for Decontamination of Platelet Concentrates," Blood 74:517 (1989).
P. Morel et al., "Photochemical Inactivation of Viruses and Bacteriophage in Plasma and Plasma Fractions," Blood Cells 18:27 (1992).
Hyde and Hearst, "Binding of Psoralen Derivatives to DNA and Chromatin: Influence of the Ionic Environment on Dark Binding and Photoreactivity," Biochemistry 17:1251 (1978).
Thompson et al., "Determination of the Secondary Structure of Drosphila Melanogaster 5 S RNA by Hydroxymethyltrimethylpsoralen Crosslinking," J. Mol. Biol. 147:417 (1981).
Thompson et al., "Dependence of 4'-(Hydroxymethyl)-4,5',8-trimethylpsoralen Photoaddition on the Conformation of Ribonucleic Acid," Biochemistry 21:1363 (1982).
Bender, et al., "Psoralen Synthesis. Improvements in Furano Ring Formation. Application to the Synthesis of 4,5',8-Trimethylpsoralen," J. Org. Chem. 44:2176 (1979).
Bender, et al., "Synthesis and Derivitization of 8-Acetylpsoralens. Acetyl Migrations during Claisen Rearrangement," J. Org. Chem. 48:2709 (1983).
Hanson, C. V., et al., "Application of a Rapid Microplaque Assay for Determination of Human Immunodeficiency Virus Neutralizing Antibody Titers," J. Clin. Micro 28:2030 (1990).
Carroll Peter G.
Cimino George D.
Isaacs Stephen T.
Carroll Peter G.
Marschel Ardin H.
Steritech, Inc.
Wilke Kathryn P.
Zitomer Stephanie W.
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