Inactivation of non-A, non-B hepatitis agent

Details Inactivation of non-A, non-B hepatitis agent Inactivation of non-A, non-B hepatitis agent

1980-05-16

1981-09-22

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Lymphokine

435238, A61K 3929

Patent

active

042910200

ABSTRACT:
This invention relates to a method of inactivating a non-A, non-B hepatitis agent by means of formalin utilized in extended treatment. The range of formalin treatment utilizes a concentration of 1:1,000-1:10,000, preferred 1:1,000, and the duration of treatment is from 24-120 hours at any temperature with a preferred 96 hours (4 days) at 37.degree..+-.4.degree. C. This formalin-treated or otherwise inactivated agent, or portions of the agent, may be later used to produce a vaccine against non-A, non-B hepatitis.

REFERENCES:
Wester Mann et al. Zentralec. Bakteriol. Parasitenk D. Infeckionskr. Hyg. ABT. I: Reihe A, 1978 240(2):143-151, Studies on the Effect of Formaldehyde on the Immunological Reactivity and Morphology of Hepatitis B-Antigens.
Tabor et al., Lancet, Mar. 4, 1978, pp. 463-466 Transmission of Non-A, Non-B Hepatitis from Man to Chimpanzee.
Tabor et al. Acute Non-A Non-B Hepatitis Prolonged Presence of the Infectious Agent in the Blood Gastroenterology 1979 Apr. 76(4):680-4.
Tabor et al. Inactivation of an Agent of Human Non-A, Non-B Hepatitis by Formalin (unpublished).

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