Inactivating protein synthesis by incubating anti-Thy 1.1-ricin

Details Inactivating protein synthesis by incubating anti-Thy 1.1-ricin Inactivating protein synthesis by incubating anti-Thy 1.1-ricin

1982-02-19

1985-05-28

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Lymphokine

514 8, A61K 3944, A61K 39395, A61K 4505

Patent

active

045200114

ABSTRACT:
The rate of protein synthesis inhibition is significantly increased by adding excess ricin B chain to target cells independent of the amount of ricin A chain bound to the cell surface membrane. Ricin is a known toxin from albumin of the castor oil bean and contains an A chain and a B chain for binding to receptors. The present invention is concerned with ricin hybrids such as OX-7-ricin A chain and 19E12-F(ab) ricin A chain which were produced by conjugation of the ricin A chains with anti-Thy 1.1 monoclonal antibodies. The conjugates were utilized in pharmaceutical amounts in mice.

REFERENCES:
patent: 4356117 (1982-10-01), Neville et al.
patent: 4359457 (1982-11-01), Neville, Jr. et al.
patent: 4397843 (1983-08-01), Neville et al.
Youle et al., Proc. Natl. Acad. Sci., U.S.A., vol. 77, No. 9, pp. 5483-5486 (1980).
Masuho et al., Biochem. Biophys. Res. Comm., 90: 320-326 (1979).
Neville/Youle, Immunology Reviews, vol. 62, p. 135, 1981.
Vallera et al., "Bone Marrow Transplantation Across Major Histocompatibility Barriers".

Affiliated with

Also associated with

Rating

Inactivating protein synthesis by incubating anti-Thy 1.1-ricin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inactivating protein synthesis by incubating anti-Thy 1.1-ricin , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inactivating protein synthesis by incubating anti-Thy 1.1-ricin will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-868377