Inactivated CD8+ T-cells for the treatment of HIV infection

Details Inactivated CD8+ T-cells for the treatment of HIV infection Inactivated CD8+ T-cells for the treatment of HIV infection

2005-11-30

2010-06-22

Nolan, Patrick J (Department: 1648)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Reexamination Certificate

active

07740855

ABSTRACT:
A method for the preparation of a T cell vaccine for the treatment of immunodeficient HIV-infected patients is described herein, based on the enrichment of autologous CD4-reactive CD8 T cells. Also described is a protocol for the implementation of T cell vaccination in immunodeficient HIV-infected, as well as a method of treatment, based on the T cell vaccine developed herein. Finally, kits for preparing the T cell vaccine as well as for implementing the protocol are also provided.

REFERENCES:
Abulafia-Lapid et al., T-cell vaccination against anti-CD4 autoimmunity in HIV-1 infected patients, Journal of Clinical Virology, 2004, 31S: S48-S54.
Abulafia-Lapid et al., T-cell vaccination against anti-CD4 autoimmunity in HIV-1 subtypes B and C-infected patients-An extended open trial, Vaccine, 2005, 23: 2149-2153.
Grube et al., An APC for every occasion: induction and expansion of human Ag-specific CD4 and CD8 T cells using cellular and non-cellular APC, Cytotherapy, 2004, 6(5):440-449.
Atlan et al., Mechanisms of autoimmunity and AIDS : prospects for therapeutic intervention, Research in Immunology, 1994, 145(3):165-183.
Schroers et al., Lentiviral transduction of human T-lymphocytes with a RANTES intrakine inhibits human immunodeficiency virus type 1 infection, Gene Therapy, 2002, 9:889-897.
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PCR protocol by Kramer and Coen (2001)Current Protocols in Molecular Biology, John Wiley & Sons, Inc., 15.1.1-15.1.4.
Skeleton staining protocol by Selby, P. (1987)Stain Technology, vol. 62, No. 3, pp. 143-146.
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