In vivo use of human bone marrow for investigation and productio

Details In vivo use of human bone marrow for investigation and productio In vivo use of human bone marrow for investigation and productio

1994-02-10

1997-05-27

Chambers, Jasemine C.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

424 92, 424 937, 424549, 424577, 424578, 424580, 424582, 424579, 800DIG5, 623 11, A61K 4900, A61K 4800

Patent

active

056334265

ABSTRACT:
Chimeric immunocompromised hosts are provided, comprising human bone marrow of at least 4 weeks from the time of implantation. The bone marrow is found to assume the normal population of bone marrow except for erythrocytes. The bone marrow may be used to study the effect of various agents on the proliferation and differentiation of hematopoietic cells.

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McCune et al., Science 241: 1632-1639 (1988).
Kamel-Reid et al., Science 242: 1706-1709 (1988).
Groscurth et al., Anat. Embryol. 165: 291-302 (1982).
Tach et al., Diabetes 33: 1180-1187 (1984).
Bastert et al., Endo. 101(2): 365-368 (1977).

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