Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1994-11-28
1998-02-24
Feisee, Lila
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
5303877, 5303888, 53038883, 435 4052, 435 723, 436504, G01N 33567, G01N 33574, C12Q 102
Patent
active
057209375
ABSTRACT:
In vivo assay methods for detecting tumors having amplified expression of the HER2 receptor are disclosed. In the assay, cells within the body of a mammal are exposed to an antibody which specifically binds to the extracellular domain of the HER2 receptor and inhibits growth in vitro of SK-BR-3 breast tumor cells which overexpress p185.sup.HER2. The antibody is generally tagged with a radioactive isotope to permit the extent of binding of the antibody to the cells to be quantified.
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Fendly Brian M.
Hudziak Robert M.
Ullrich Axel
Bansal Geetha P.
Feisee Lila
Genentech Inc.
Lee Wendy M.
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