Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Virus or bacteriophage
Patent
1998-01-21
2000-12-12
Bansal, Geetha P.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Virus or bacteriophage
424 92, 435 712, 4353201, 514 44, A61K 4800, A01N 6300, C12P 2104, C12N 1500
Patent
active
061594679
ABSTRACT:
A therapeutic agent based on a recombinant adenovirus which employs an osteocalcin promoter for the expression of thymidine kinase can be administered intravascularly to treat metastatic cancer, including osteosarcoma, breast cancer, prostate cancer, ocular melanoma or brain cancer. Systemic administration of this agent provides a preferred route over previous disclosure of local direct administration. The same therapeutic agent can be effectively employed in the treatment of benign conditions, including benign prostatic hypertrophy and arteriosclerosis.
REFERENCES:
patent: 5631236 (1997-05-01), Woo et al.
Human Gene Therapy, 7(4) 463-70, Mar. 1, 1996, Su. et al., Selective Killing of AFP-Positive Hepatocellular Carcinoma Cells by Adeno-Associated Virus Transfer of the Herpes Simplex Virus Thymidine Kinase Gene.
Cancer Research, 56(20) 4614-9, Oct. 15, 1996, Ko. et al., Osteocalcin Promoter-Based Toxic Gene Therapy for the Treatmetn of Osteosarcoma in Experimental Models.
Cheon Jun
Chung Leland W. K.
Kao Chinghai
Ko Song-Chu
Sikes Robert A.
Bansal Geetha P.
The University of Virginia Patent Foundation
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