Multicellular living organisms and unmodified parts thereof and – Method of using a transgenic nonhuman animal in an in vivo...
Reexamination Certificate
2007-04-10
2007-04-10
Wilson, Michael C. (Department: 1632)
Multicellular living organisms and unmodified parts thereof and
Method of using a transgenic nonhuman animal in an in vivo...
C800S008000, C800S018000
Reexamination Certificate
active
10470818
ABSTRACT:
The invention features methods of evaluating the effect of a plurality of different treatments or compounds on a tissue. The method includes providing a tissue from an animal; contacting the tissue with a plurality of treatment, forming on the tissue an array of a plurality of regions or addresses. The method includes the use of a two dimensional array member to contact the plurality of treatments with the tissue and/or to evaluate their effect. The methods are useful for screening large numbers of therapeutic or cosmetic compounds.
REFERENCES:
patent: 4914022 (1990-04-01), Furmanski et al.
patent: 5648061 (1997-07-01), Bernstein et al.
patent: 5735288 (1998-04-01), Fishman
patent: 5753439 (1998-05-01), Smith et al.
patent: 6083763 (2000-07-01), Balch
patent: 6118044 (2000-09-01), Karasuyama et al.
patent: 6183995 (2001-02-01), Burmer et al.
patent: WO 99/30743 (1999-06-01), None
Kappel et al. Current Biology, 1992, 3: 548-553.
Mullins et al. Hypertension, 1993, 22: 630-633.
Houdebine et al. Journal of Biotechnology, 1994, 34: 269-287.
Wall R.J. Theriogenology, 1996, 45: 57-68.
Mullins et al. Journal of Clinical Investigation, 1996, 98(11): S37-S40.
Cameron E. Molecular Biology, 1997, 7: 253-265.
Sigmund C. Arterioscler. Thromb. Vasc. Biol., 2000, 20: 1425-1429.
Niemann H. Transgenic Research, 1998, 7: 73-75.
“Induced Mutant Resource (IMR) Transgenic and Targeted Mutant Mice,” The Jackson Laboratory, http://web.archive.org/web/20000901042229/www.jax.org/resources . . . downloaded Dec. 22, 2005.
Markkula, et al., “Transgenic Animals and Gonadotrophins,”Reviews of Reproduction1: 97-106 (1996).
Missero et al., “Skin-specific Expression of a Truncated Ela Oncoprotein Binding to p105-Rb Leads to Abnormal Hair Follicle Maturation Without Increased Epidermal Proliferation,”J. Cell Bio. 121(5):1109-20, Jun. 1993.
Wolf et al., “Use of Transgenic Animals in Understanding Molecular Mechanisms of Toxicity”,J. Pharm. Pharmacol. 50: 567-74 (1998).
The General Hospital Corporation
Wilson Michael C.
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