In vivo phenotyping for human cytochrome P450 3A activity

Details In vivo phenotyping for human cytochrome P450 3A activity In vivo phenotyping for human cytochrome P450 3A activity

2005-06-14

2005-06-14

Leary, Louise N. (Department: 1654)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

C435S018000, C435S004000

Reexamination Certificate

active

06905839

ABSTRACT:
In a method for evaluating in vivo human cytochrome P450 3A (CYP3A), at least a 2-hour urine collection and one blood sample are obtained. Endogenous cortisol in plasma and 6β-hydroxycortisol in urine are measured. Metabolic clearance specific for the 6β-hydroxylation of cortisol is then expressed as the amount of urinary excreted 6β-hydroxycortisol divided by the area under the concentration-time curve of cortisol, being a safe and reliable index for CYP3A phenotyping to assess in vivo CYP3A activity in humans.

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