In vivo panning for ligands to radiation-induced molecules

Details In vivo panning for ligands to radiation-induced molecules In vivo panning for ligands to radiation-induced molecules

2008-07-22

2008-07-22

Wessendorf, T. D. (Department: 1639)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S006120, C435S005000, C435S004000, C435S091500, C435S091500, C435S235100

Reexamination Certificate

active

07402392

ABSTRACT:
A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. The method includes the steps of: (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are therapeutic and diagnostic methods using targeting ligands that bind an irradiated tumor.

REFERENCES:
patent: 6159443 (2000-12-01), Hallahan
patent: 7018615 (2006-03-01), Ruoslahti et al.
patent: 7056506 (2006-06-01), Varner
patent: 7138238 (2006-11-01), Vodyanoy et al.
patent: 2002/0164663 (2002-11-01), Fuqua et al.
patent: 2003/0083261 (2003-05-01), Yu et al.
Pasqualini et al, Molecular Psychiatry, 1996,1, 423.
Barry et al, Nature Medicine, 2(3) (Mar. 1996), 299-305.
International Search Report for corresponding PCT Appl. No. PCT/US02/30917 dated Feb. 10, 2005.
Hallahan et al., “Targeting Drug Delivery to Radiation-induced Neoantigens in Tumor Microvasculature”,Journal of Controlled Release, 74: 183-191, 2001.
Hallahan et al., “X-Ray-induced P-Seectin Localization to the Lumen of Tumor Blood Vessels”,Cancer Research, 58: 5216-5220, Nov. 15, 1998.
Lieberman et al., “A Human Homolog of the Schizosaccharomyces Pombe rad9 Check Point Control Gene”,Proceedings of the National Academy of Sciences, 93: 13890-13895, Nov. 1996.
Database HCAPLUS on STN, ACS (Columbus, OH, USA) No. 2001:661624, Xu et al., “Cell Cycle Proteins PP5 Associated with rad9 and Uses in Screening for a Bioactive Agent”, Abstract, WO 01/64913, see Registry No. 263887-03-2, human gene rad9, for SEQ ID No. 8.
Database HCAPLUS on STN, ACS (Columbus, OH, USA) No. 1997:513697, Dolganov, “The Human rad50 and Septin-2 Genes and their Roles in Myelodysplastic diseases and their Diagnostic and Therapeutic Uses”, Abstract, WO 97/27284, see Registry No. 194813-18-8, human clone B15.2, for SEQBID No. 8.
Database HCAPLUS on STN, ACS (Columbus, OH, USA) No. 2000:573954, Kastan et al., “ATM Kinase Modulation for Screening and Therapies”, WO 00/47760, see Registry No. 288259-02-9 for SEQ ID No. 8 and 10 and Registry No. 288259-18-7 for SEQ ID No. 13.
Database HCAPLUS on STN, ACS (Columbus, OH, USA) No. 1998:248017, Kurnik et al., “Prospective Study of Atrial Natriuretic Peptide for the Prevention of Radio-Contrast-Induced Nephropathy”, Abstract,American Journal of Kidney Diseases, 1998, see Registry No. 95896-08-5, atrial natriuretic peptide-25, for SEQ ID No. 11.
Database HCAPLUS on STN, ACS (Columbus, OH, USA) No. 1998:365000, Croce et al., “Cloning of Human rad54 Gene Homolog and its Diagnostic and Therapeutic uses”, EP 844,305, see Registry No. 208601-90-5, human rad54, for SEQ ID No. 12.

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