In vivo method of determining leucocyte migratory activity level

Details In vivo method of determining leucocyte migratory activity level In vivo method of determining leucocyte migratory activity level

1980-01-31

1982-12-28

Fagelson, Anna P.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

424 49, 424177, 436530, 436811, A61K 4900, G01N 3348, G01N 3350

Patent

active

043661440

ABSTRACT:
Pharmacologically acceptable chemotactic agents when applied to gingival crevices cause the migration of crevicular fluid containing crevicular leucocytes into the said gingival crevice.
A quantitative correlation has been found between the amount of crevicular fluid migrating into the crevice and the crevicular fluid migrating into the crevice and the crevicular leucocytes contained therein after chemotactic challenge.
It has further been shown that the amount of fluid and leucocytes migrating into said crevice gave a predictable relationship to the migratory activity of leucocytes obtained from the same subject when measured by conventional in vitro means.
A rapid, convenient and simple method is thus provided for detecting certain diseases involving leucocyte migratory activity abnormalities for example diabetes mellitus and periodontosis.

REFERENCES:
Golub et al., Chem. Abs., vol. 85, 1976, Ab. No. 85:175020p.
Ramamurthy, Siegel, Iacono & Golub, J. Periodont Res., vol. 14, Jul. 1979, pp. 289-296.
Hase, J. Periodontal Res., vol. 14, 1979, pp. 153-159.
Budtz-Jorgensen, J. Periodontal Res., vol. 12, 1977, pp. 21-29.
Kraal, J. Periodontal Res., vol. 12, 1977, pp. 242-249.
Golub, Oral Sci. Rev., vol. 8, 1976, pp. 49-61.

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