Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Diagnostic or test agent produces in vivo fluorescence
Patent
1993-12-09
1995-09-26
Killos, Paul J.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Diagnostic or test agent produces in vivo fluorescence
604 19, 604 21, 606 2, 606 15, 514824, A61K 4700, A61N 130
Patent
active
054534488
ABSTRACT:
Cardiovascular disease is the leading cause of death in the United States. Interpreting the relative danger of a lesion within the vasculature is limited by a lack of information on the composition of lesion. It is believed that a lesion which is high in lipids is more prone to rupture followed by thrombosis than a stable highly calcific, fibrotic, high grade stenosis. To address this recent hypothesis, a method of diagnosing and treating the most problematic vascular lesions is presented. The method employs the selective uptake of a lipophilic fluorescent compound by a lesion followed by the application of excitation light to the fluorescent compound-ladened lesion causing the fluorescent compound to emit fluorescence light. The intensity of the fluorescence light indicates the lipid content and/or the fibrous cap thickness, thus providing information on the potential danger of the lesion and enabling the clinician to treat the lesion in a manner which provides the patient with the best chance for clinical success.
REFERENCES:
91:116051 Medline 1990.
91:521953 Biosis 1991.
V. Fuster, et al., Clinical Pathoglogical . . . , Suppl. to Circulation 86, No. 6, 1992.
J. J. Badimon, Coronary Atherosclerosis . . . Suppl. to Circulation 87, No. 3,1993.
E. Falk, Why Do Plaques Rupture, Suppl. to Circulation 86, No. 6, 1992.
D. Kessel, et al., Porphyrin Accumulation . . . , Photochem. Photobiol. 40 No. 1 1984.
Killos Paul J.
PDT Cardiovascular, Inc.
Petit Michael G.
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