In vivo method for determination of oxidative stress

Details In vivo method for determination of oxidative stress In vivo method for determination of oxidative stress

2000-01-18

2000-10-17

Warden, Jill

Chemistry: analytical and immunological testing

Peptide, protein or amino acid

Amino acid or sequencing procedure

436 86, 436811, G01N 3300

Patent

active

061330396

ABSTRACT:
A non-invasive method for the determination of oxidative stress in a patient by urinalysis is disclosed. The method comprises quantifying the level of o,o'-dityrosine in a sample of the urine of said patient and comparing with the corresponding level of said compound in a normal or control sample, whereby a substantially elevated level of said o,o'-dityrosine is indicative of oxidative stress in said patient.

REFERENCES:
patent: 5731208 (1998-03-01), Heinecke
Berliner & Heinecke: Free Radical Biol. & Medicine, vol. 20, pp. 707-727 (1996).
Heinecke; Cur. Opinions Lipid, vol. 8, pp. 268-274 (1997).
Heinecke et al; J. Biol. Chem., vol 268, pp. 4069-4077 (1993).
Leeuwenburgh et al; J. Biol. Chem. vol. 272, pp. 3520-3526 (1997).
Heinecke et al; J. Clin. Invest., vol. 91, pp. 2866-2872 (1993).
Leeuwenburgh et al; Am. J. Physiol., vol. 274, pp. R453-R461 (1998).
Leeuwenburgh et al; Free Radical Biol. & Medicine, vol. 27, pp. 186-192 (1999).
Jacob et al; J. Biol. Chem., vol. 271, pp. 19950-19956 (1995).
McCormick et al; J. Biol. Chem., vol. 273, pp. 32030-32037 (1998).
Leeuwenburgh et al; Arch. Biochem. Biophys., vol. 346, pp. 74-80 (1997).
Leeuwenburgh et al; J. Biol. Chem., vol. 272, pp. 1433-1436 (1997).
Hazen & Heinecke; J. Clin. Invest., vol. 99, pp. 2075-2081 (1997).
Hazen et al.; J. Biol. Chem., vol. 271, pp. 1861-1867 (1996).
Heinecke; FASEB J., Col. 13, pp. 1113-1120 (1999).

Affiliated with

Also associated with

Rating

In vivo method for determination of oxidative stress does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with In vivo method for determination of oxidative stress, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and In vivo method for determination of oxidative stress will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-467468