Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1999-04-08
2000-04-18
Hollinden, Gary E.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
600420, A61B 5055
Patent
active
060512083
ABSTRACT:
Nuclear magnetic resonance (NMR) images of a human or animal subject's vascular system are enhanced by injecting a liquid comprised of a biocompatible liquid carrier and a dispersion of hyperpolarized gas microbubbles into the subject, followed by generating an image by NMR representing a spatial distribution of the hyperpolarized gas microbubbles injected into the human or animal subject's vascular system. Preferably, the hyperpolarized gas is Helium-3 and/or Xenon-129. The microbubbles most preferably have a mean diameter of less than about 35 .mu.m.
REFERENCES:
patent: 5785953 (1998-07-01), Albert et al.
patent: 5809801 (1998-09-01), Cates, Jr. et al.
In vivo magnetic resonance vascular imaging using laser-polarized .sup.3 He microbubbles; Mark S. Chawla, et al; Proc. Natl. Acad. Sci. USA; vol. 95, pp. 10832-10835, Sep. 1998, Medical Sciences.
Biological magnetic resonance imaging using laser-polarized .sup.129 Xe; M.S. Albert, et al.; Department of Chemistry, State University of New York, Stony Brook, New York 11794-3400, USA; Department of Physics, Princeton University, Princeton, New Jersey 08544, USA; Letters of Nature, pp. 199-201 Jul. 1994.
MR Imaging with Hyperpolarized .sup.3 He Gas; Hunter Middleton, et al., MRM 33:271-275 (1995); Department of Physics, Princeton University, Princeton, NJ; Depts. Of Biomedical Engineering and Physics, Duke University, Durham, NC; pp. 271-275.
In Vivo He-3 MR Images of Guinea Pig Lungs; Robert D. Black, et al., Technical Developments and Instrumentation; Center for in Vivo Microscopy, Duke University, pp. 867-870 (1996).
In Vivo MR Imaging and Spectroscopy Using Hyperpolarized .sup.129 Xe; Mark E. Wagshul, et al.; MRM 36:183-191 (1996); Depts. Radiology and Chemistry.
NMR of laser-polarized xenon in human blood (optical pumping/laser-polarized xenon); A. Bifone et al.; Proc. Natl. Acad. Sci. USA, vol. 93, pp. 12932-12936, Nov. 1996, Biophysics.
In vivo NMR and MRI using injection delivery of laser-polarized xenon; B.M. Goodson et al.; Proc. Natl. Acad. Sci. USA, vol. 94, pp. 14725-14729, Dec. 1997, Medical Sciences.
Brain MRI with Laser-Polarized .sup.129 Xe; Scott D. Swanson et al.; MRM 38:695-698 (1997).
Solubility of inert gases in biological fluids and tissues: a review; P.K. Weathersby and L.D. Homer, Naval Medical Research Institute, Bethesda, MD 20014; pp. 277-296 (1980).
Polarization of the nuclear spins of noble-gas atoms by spin exchange with optically pumped alkali-metal atoms; W. Happer, et al; Department of Physics, Princeton University, Princeton, NJ 08544 .COPYRGT. 1984 The American Physical Society; pp. 3092-3110 (1984).
Polarized, high-density, gaseous .sup.3 He targets; T.E. Chupp et al; Physical Review C, vol. 36, No. 6, Dec. 1987, pp. 2244-2251.
Nuclear relaxation of.sup.3 He in the presence of O.sub.2 ; B. Saam, et al., Physical Review A, vol. 52, No. 1, Jul. 1995; pp. 862-865.
Myocardial Contrast Echocardiography: A Reproducible Technique of Myocardial Opacification for Identifying Regional Perfusion Deficits; Chuwa Tel, M.D., et al.; Dept. of Medicine, Univ. of California School of Medicine, Wadsworth Veterans Administration Medical Center and Cedars-Sinai Medical Center, Los Angeles, CA; pp. 585-593 (1983).
Dynamics of Magnetization in hyperpolarized Gas MRI of the Lung; C. Allan Johnson, et al.; MRM 38:66-71 (1997).
MR Microscopy of Lung Airways with Hyperpolarized .sup.3 He; X. Josette Chen, et al; MRM 39:79-84 (1998).
Three-Dimensional Time-of-Flight Magnetic Resonance Angiography Using Spin Saturation; C.L. Dumoulin et al; General Electric Research and Development Center; MRM 11:35-46 (1989).
Mirobubble Dynamics Visualized in the Intact Capillary Circulation; StevenB. Feinstein, MD, et al.; JACC, vol. 4, No. 3, Sep. 1984, 595-600.
Nuclear Magnetic Resonance Imaging of Airways in Humans with Use of Hyperpolarized .sup.3 He; Peper Bachert, et al; MRM 36:192-196 (1996).
Contrast Echyocardiography; J.W. Winkelmann, et al.; University of Illinois at Chicago, Chicago, IL, pp. 507-515 (1994).
Principles and Practice of Nuclear Medicine; Paul J. Early et al.; Second Edition; pp. 376-420 (1995).
A Rapid-Gated Cine MRI Technique; Gary H. Glover et al.; Magnetic Resonance Annual 1988; pp. 299-333.
Chawla Mark S.
Johnson G. Allan
Duke University
Hollinden Gary E.
LandOfFree
In vivo magnetic resonance vascular imaging using laser-polarize does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with In vivo magnetic resonance vascular imaging using laser-polarize, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and In vivo magnetic resonance vascular imaging using laser-polarize will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2334292