In vivo introduction and expression of foreign genetic material

Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses

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4351721, 435 691, 435 701, 435 703, 435235, 4352401, 4352402, 935 59, 935 62, 935 66, 935 70, 935 71, C12P 2100, C12N 1500, C12N 500, C12N 700

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049802860

ABSTRACT:
Epithelial cells expressing foreign genetic material are described. The foreign genetic material can be DNA or RNA which does not occur in epithelial cells; DNA or RNA which occurs in epithelial cells but is not expressed in them at levels which are biologically significant; DNA or RNA which occurs in epithelial and has been modified so that it is expressed in epithelial cells; and any DNA or RNA which can be modified to be expressed in epithelial cells, alone or in any combination thereof. In addition, epithelial cells of the present invention can express genetic material encoding a selectable marker by which cells expressing the foreign genetic material can be expressed.

REFERENCES:
patent: 4769317 (1988-09-01), Hefton
Burnett et al (1983), Chemical Abstract CA 99(7):5122a.

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