Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology
Reexamination Certificate
2007-01-30
2007-01-30
Lankford, Jr., Leon Blaine (Department: 1651)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of regulating cell metabolism or physiology
C424S093700, C435S289100
Reexamination Certificate
active
10607695
ABSTRACT:
The invention features a liver cell culture comprising hepatocytes that have increased detoxification enzyme activity when isolated from a liver of a donor that had been administered at least one induction agent prior isolation of hepatocyte cells. The induced hepatocytes are used in a bioreactor and cultured to produce hepatocyte cell products or metabolize toxins added to the culture. The bioreactor is, or is an integral part of, a liver assist device used to treat a patient in need of liver assist.
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DiMilla Paul A.
Gregory Paul G.
Sullivan Susan J.
Kramer Levin Naftalis & Frankel
Lankford, Jr. Leon Blaine
Organogenesis, Inc
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