In vivo incorporation of unnatural amino acids

Details In vivo incorporation of unnatural amino acids In vivo incorporation of unnatural amino acids

2011-03-29

2011-03-29

Rao, Manjunath N (Department: 1656)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Isomerase

C435S069100, C435S488000, C435S320100, C536S023500

Reexamination Certificate

active

07915025

ABSTRACT:
The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.

REFERENCES:
patent: 6927042 (2005-08-01), Schultz et al.
patent: 7045337 (2006-05-01), Schultz et al.
patent: 7083970 (2006-08-01), Schultz et al.
patent: 7129333 (2006-10-01), Schultz et al.
patent: 7183082 (2007-02-01), Schultz et al.
patent: 7199222 (2007-04-01), Schultz et al.
patent: 7217809 (2007-05-01), Schultz et al.
patent: 7238510 (2007-07-01), Schultz et al.
patent: 7262040 (2007-08-01), Schultz et al.
patent: 7354761 (2008-04-01), Schultz et al.
patent: 7368275 (2008-05-01), Schultz et al.
patent: 7378263 (2008-05-01), Schultz et al.
patent: 7399619 (2008-07-01), Xie et al.
patent: 7432092 (2008-10-01), Schultz et al.
patent: 7494796 (2009-02-01), Alfonta et al.
patent: 7524647 (2009-04-01), Schultz et al.
patent: 7527943 (2009-05-01), Anderson et al.
patent: 7560535 (2009-07-01), Schultz et al.
patent: 7575895 (2009-08-01), Anderson et al.
patent: 7608423 (2009-10-01), Chin et al.
patent: 7638297 (2009-12-01), Anderson et al.
patent: 7638300 (2009-12-01), Schultz et al.
patent: 7642085 (2010-01-01), Schultz et al.
patent: 2004/0198637 (2004-10-01), Schultz et al.
patent: 2004/0265952 (2004-12-01), Deiters et al.
patent: 2005/0009049 (2005-01-01), Chin et al.
patent: 2005/0136513 (2005-06-01), Zhang et al.
patent: 2005/0208536 (2005-09-01), Schultz et al.
patent: 2005/0227318 (2005-10-01), Alfonta et al.
patent: 2005/0250183 (2005-11-01), Schultz et al.
patent: 2005/0272121 (2005-12-01), Xie et al.
patent: 2006/0063244 (2006-03-01), Schultz et al.
patent: 2006/0073507 (2006-04-01), Deiters et al.
patent: 2006/0110784 (2006-05-01), Deiters et al.
patent: 2006/0110796 (2006-05-01), Schultz et al.
patent: 2006/0134746 (2006-06-01), Deiters et al.
patent: 2006/0160175 (2006-07-01), Anderson et al.
patent: 2006/0177900 (2006-08-01), Anderson et al.
patent: 2006/0246509 (2006-11-01), Deiters et al.
patent: 2007/0009990 (2007-01-01), Alfonta et al.
patent: 2007/0020634 (2007-01-01), Anderson et al.
patent: 2007/0042461 (2007-02-01), Anderson et al.
patent: 2007/0111193 (2007-05-01), Zhang et al.
patent: 2007/0117184 (2007-05-01), Schultz et al.
patent: 2007/0154952 (2007-07-01), Chin et al.
patent: 2007/0166791 (2007-07-01), Chin et al.
patent: 2007/0172915 (2007-07-01), Schultz et al.
patent: 2007/0178448 (2007-08-01), Tsao et al.
patent: 2007/0184517 (2007-08-01), Schultz et al.
patent: 2007/0238152 (2007-10-01), Wang et al.
patent: 2007/0281335 (2007-12-01), Ryu et al.
patent: 2008/0044886 (2008-02-01), Wang et al.
patent: 2008/0064059 (2008-03-01), Schultz et al.
patent: 2008/0113407 (2008-05-01), Liu et al.
patent: 2008/0166766 (2008-07-01), Liu et al.
patent: 2008/0166783 (2008-07-01), Schultz et al.
patent: 2008/0167243 (2008-07-01), Schultz et al.
patent: 2008/0171317 (2008-07-01), Deiters et al.
patent: 2008/0176277 (2008-07-01), Chin et al.
patent: 2008/0176284 (2008-07-01), Schultz et al.
patent: 2008/0213828 (2008-09-01), Schultz et al.
patent: 2008/0220472 (2008-09-01), Deiters et al.
patent: 2008/0227152 (2008-09-01), Schultz et al.
patent: 2008/0227153 (2008-09-01), Schultz et al.
patent: 2008/0227195 (2008-09-01), Chin et al.
patent: 2008/0233611 (2008-09-01), Schultz et al.
patent: 2008/0241903 (2008-10-01), Schultz et al.
patent: 2008/0261311 (2008-10-01), Schultz et al.
patent: 2009/0053791 (2009-02-01), Schultz et al.
patent: 2009/0068717 (2009-03-01), Schultz et al.
patent: 2009/0081690 (2009-03-01), Deiters et al.
patent: 2009/0137424 (2009-05-01), Tsao et al.
patent: 2009/0148887 (2009-06-01), Brustad et al.
patent: 2009/0163368 (2009-06-01), Liu et al.
patent: 2009/0181429 (2009-07-01), Ryu et al.
patent: 2009/0181858 (2009-07-01), Deiters et al.
patent: 2009/0197339 (2009-08-01), Young et al.
patent: 2009/0208994 (2009-08-01), Seyedsayamdost et al.
patent: 2009/0209000 (2009-08-01), Wang et al.
patent: 2009/0215117 (2009-08-01), Schultz et al.
patent: 2009/0227002 (2009-09-01), Schultz et al.
patent: 2009/0263376 (2009-10-01), Grunewald et al.
patent: 2009/0286279 (2009-11-01), Liu et al.
patent: 2009/0298119 (2009-12-01), Wang et al.
patent: 2009/0298124 (2009-12-01), Alfonta et al.
patent: 2010/0009425 (2010-01-01), Schultz et al.
patent: 2010/0021963 (2010-01-01), Liu et al.
patent: WO 2009/064416 (2009-05-01), None
patent: WO 2009/151491 (2009-12-01), None
Hamano-Takaku et al. “A MutantEscherichia coliTyrosyl-tRNA Synthetase Utilizes the Unnatural Amino Acid Azatyrosine More Efficiently than Tyrosine.”, J. Biol. Chem., vol. 275, Issue 51, 40324-40328, 2000.
Labarre et al Journal of Bacteriology, Oct. 1987, p. 4668-4673.
Anderson et al., Exploring the Limits of Codon and Anticodon Size,Chemistry and Biology, vol. 9, 237-244 (2002).
Azoulay et al., Glutamine analogues as Potential Antimalarials,.Eur. J. Med. Chem. 26, 201-5 (1991).
Bain et al., Biosynthetic site-specific Incorporation of a non-natural amino acid into a polypeptide,J. Am. Chem. Soc., 111:8013-8014 (1989).
Barton et al., Synthesis of Novel a-Amino-Acids and Derivatives Using Radical Chemistry: Synthesis of L- and D-a-Amino-Adipic Acids, L-a-aminopimelic Acid and Appropriate Unsaturated Derivatives.Tetrahedron Lett. 43, 4297-4308 (1987).
Boles et al.,Nat. Struct. Biol., 1:283 (1994).
Bradley et al., tRNA2Gln Su+2 mutants that increase amber suppression,J. Bacteriol. 145:704-712 (1981).
Brick et al.,J. Mol. Biol., 208:83-98 (1988).
Brunner, New Photolabeling and crosslinking methods,Annu. Rev. Biochem., 62:483-514 (1993).
Budisa et al.,Eur. J. Biochem., 230:788 (1995).
Budisa et al.,FASEB J. 13:41-51 (1999).
Budisa et al.,J. Mol. Biol., 270:616 (1997).
Budisa et al.,Proc. Natl. Acad. Sci. U S A, 95:455 (1998).
Christie & Rapoport, Synthesis of Optically Pure Pipecolates from L-Asparagine. Application to the Total Synthesis of (+)-Apovincamine through Amino Acid Decarbonylation and Iminium Ion Cyclization.J. Org. Chem. 50:1239-1246 (1985).
Cornish et al.,Angew. Chem. Int. Ed. Engl., 34:621 (1995).
Cornish et al.,J. Am. Chem. Soc., 118:8150-8151 (1996).
Craig et al., Absolute Configuration of the Enantiomers of 7-Chloro-4 [[4-(diethylamino)-1-methylbutyl]amino]quinoline (Chloroquine).J. Org. Chem. 53, 1167-1170 (1988).
Database NCBI, GenBank Accession No. E64348, Bult et al. ‘Complete genome sequence of the methanogenic archaeon,Methanococcus jannaschii,’ Gene Sequence, Jun. 3, 1996.
Doctor & Mudd,J. Biol. Chem., 238:3677 (1963).
Doring et al.,Science, 292:501 (2001).
Dougherty,Curr. Opin. Chem. Biol., 4:645 (2000).
Duewel et al.,Biochemistry, 36:3404 (1997).
Dunten & Mowbray, Crystal structure of the dipeptide binding protein fromEscherichia coliinvolved in active transport and chemotaxis.Protein Science4, 2327-34 (1995).
Ellman et al., Biosynthetic method for introducing unnatural amino acids site-specifically into proteins,Methods in Enz., 202:301-336 (1992).
Ellman et al., Site-specific incorporation of novel backbone structures into proteins,Science, 255:197-200 (1992).
England et al.,Cell, 96:89 (1999).
Fechter et al., Major tyrosine identity determinants inMethanococcus jannaschiiandSaccharomyces cerevisiaetRNATyr are conserved but expressed differently,Eur. J. Biochem. 268:761-767 (2001).
Francisco et al., Production and fluorescence-activated cell sorting ofEscherichia coliexpressing a functional antibody fragment on the external surface.Proc Natl Acad SciU S A. 90:1.0444-8 (1993).
Francklyn et al. (2002) “Aminoacyl-tRNA synthetases: Versatile players in the changing theater of translation.”RNA, 8:1363-1372.
Friedman & Chatterrji, Synthesis of Derivatives of Glutamine as Model Substrates for Anti-Tumor Agents.J. Am. Chem. Soc. 81, 3750-3752 (1959).
Furter,Protein Sci., 7:419 (1998).
Gabriel & McClain, A set of plasmids constitutively producing different RNA levels inEscherichia coli, J. Mol. Biol. 290 (1999) 385-389.
Gallivan et al.,Chem. Biol., 4:739 (1997).
GenBank Accession No. Q57834.
Giegé et al.,Biochimie, 78:605 (1996).
Gi

Affiliated with

Also associated with

Rating

In vivo incorporation of unnatural amino acids does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with In vivo incorporation of unnatural amino acids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and In vivo incorporation of unnatural amino acids will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2780726