In vivo high throughput toxicology screening method

Details In vivo high throughput toxicology screening method In vivo high throughput toxicology screening method

2005-02-15

2005-02-15

Chin, Christopher L. (Department: 1641)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C424S009100, C424S009200, C435S007210, C435S007220, C435S007310, C435S007320, C435S004000, C435S029000, C436S501000, C436S815000

Reexamination Certificate

active

06855504

ABSTRACT:
A high throughput toxicology screening method is provided. In the subject method, at least 10 different compound compositions are tested simultaneously. Each compound composition is tested by contacting it with a plurality, e.g. from about 10 to 1000, of non-mammalian multi-cellular organisms and determining the effect of the compound composition on the organisms. The multi-cellular organisms employed in the subject methods are small, have differentiated tissues and organs and have a rapid generation time. The subject high throughput screening methods find use in a variety of applications, and are particularly suited for use in the toxicology screening of libraries of compounds, such as libraries of combinatorially produced compounds.

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