In vivo gene transfer methods for wound healing

Details In vivo gene transfer methods for wound healing In vivo gene transfer methods for wound healing

1996-04-12

1999-10-05

Campbell, Bruce R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

4353201, 435325, 435455, 435458, 536 245, 424 9321, A61K 4800

Patent

active

059624272

ABSTRACT:
The present invention relates to an in vivo method for specific targeting and transfer of DNA into mammalian repair cells. The transferred DNA may include any DNA encoding a therapeutic protein of interest. The invention is based on the discovery that mammalian repair cells proliferate and migrate into a wound site where they actively take up and express DNA. The invention further relates to pharmaceutical compositions that may be used in the practice of the invention to transfer the DNA of interest. Such compositions include any suitable matrix in combination with the DNA of interest.

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