In vivo expanded NKT cells and methods of use thereof

Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Animal or plant cell

Reexamination Certificate

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C435S377000

Reexamination Certificate

active

07837990

ABSTRACT:
This invention relates to the in vivo expansion of NKT cells by their exposure to mature dendritic cells expressing α-galactosyl ceramide and to methods of use thereof in modulating immune responses, such as anti-cancer responses, and enhancing memory responses.

REFERENCES:
patent: 5405772 (1995-04-01), Ponting
patent: 2002/0164331 (2002-11-01), Exley et al.
patent: 2003/0157135 (2003-08-01), Tsuji et al.
patent: WO 93/20185 (1993-10-01), None
patent: WO 95/00632 (1995-01-01), None
patent: WO 95/06112 (1995-03-01), None
Mortreux et al, Leukemia, 2003, vol. 17, , pp. 26-38.
Bender, A. et al. “Improved Methods for the Generations of Dendritic Cells from NonProliferating Progenitors in Human Blood,”J. Immunol. Methods196 121-135 (1996).
O'Doherty, U. et al., “Dendritic Cells Freshly Isolated from Human Blood Express CD4 and Mature into Typical Immunostimulatory Dendritic Cells After Culture in Monocyte-Conditioned Medium,”J. Exp. Med. 178: 1067-1078 (1993).
Bonifaz, L. et al., “Efficient Targeting of Protein Antigen to the Dendritic Cell Receptor DEC-205 in the Steady State Leads to Antigen Presentation on Major Histocompatibility Complex Class I Products and Peripheral CD8+T Cell Tolerance,”J. Exp. Med. 196(12) 1627-1638 (2002).
Manavalan, J.S., et al. “High Expression of ILT3 and ILT4 is a General Feature of Tolerogenic Dendritic Cells,”Transpl. Immunol. 11: 245-258 (2003).
Romani, N. et al., “Proliferating Dendritic Cell Progenitors in Human Blood,”J. Exp. Med. 180: 83-93 (1994).
O'Doherty, U. et al. “Human Blood Contains Two Subsets of Dendritic Cells, One Immunologically Mature and the Other Immature,”Immunology82 487-493, (1994).
Steinman, R. M., et al., “Tolerogenic Dendritic Cells”Annu. Rev. Immunol. 21, 685-711, (2003).
Banchereau, J., et al., “Immunobiology of Dendritic Cells,”Annu. Rev. Immunol., 18,767-811, (2000).
Mellman, I. et al., “Dendritic Cells: Specialized and Regulated Antigen Processing Machines,”Cell106, 255-258 (2001).
Steinman, R. M. et al., “Avoiding Horror Autotoxicus: The Importance of Dendritic Cell in Peripheral T Cell Tolerance,”Cell Proc. Natl. Acad. Sci. USA99, 351-358, (2002).
Brimnes, M. K., et al., “Influenza Virus-Induced Dendritic Cell Maturation is Associated with the Induction of Strong T Cell Immunity to a Coadministered, Normally Nonimmunogenic Protein,”J. Exp. Med. 198,133-144, (2003).
Regnault, A. et al. “FCγ Receptor-Mediated Induction of Dendritic Cell Maturation and major Histocompatibility Complex Class I-Restricted Antigen Presentation After Immune Complex Internalization,”J. Exp. Med. 189, 371-380 (1991).
Ravetch, J. V. et al., “IgG Fc Receptors”,Annu. Rev. Immunol., 19, 275-290, (2001).
Bolland, S. et al. “Genetic Modifiers of Systemic Lupus Erythematosus in FcγRIIB-/-Mice,”J. Exp. Med. 195, 1167-1174 (2002).
Bolland, S. et al. “Spontaneous Autoimmune Disease in FcγRIIB-Deficient Mice Results from Strain-Specific Epistasis”,Immunity13, 277-285 (2000).
Clynes, R. A. et al. “Inhibitory Fc Receptors Moduclate in vivo Cytoxicity Against Tumor Targets”,Nat. Med. 6(4), 443-446 (2000).
Bolland,S. et al., “SHIP Modulates Immune Receptor Responses by Regulating Membrane Association of Btk”,Immunity8, 509-516, (1998).
Bolland, S. et al., “Inhibitory Pathways Triggered by ITIM-Containing Receptors,”Adv. Immunol., 72, 149-177, (1999).
Amigorena, S. “Feγ Receptors and Cross-Presentation in Dendritic Cells,”J. Exp. Med. 195, F1-F3, (2002).
Dhodapkar, K. et al. “Antitumor Monoclonal Antibodies Enhance Cross-Presentation of Cellular Antigens and the Generation of Myeloma-Specific Killer T Cells by Dendritic Cells,”J. Exp. Med. 195,125-133 (2002).
Selenko, N. et al. “Cross-Priming of Cytotoxic T Cells Promoted by Apoptosis-Inducing Tumor Cell Reactive Antibodies?”J. Clin. Immunol. 22, 124-130, (2002).
Kita, H. et al. “Identification of HLA-A2-Restricted CD8+ Cytotoxic T Cell Responses in Primary Biliary Cirrhosis: T Cell Activation is Augmented by Immune Complexes Cross-Presented by Dendritic Cells,”J. Exp. Med. 195,113-123, (2002).
Nagata, Y. et al. “Differential Presentation of a Soluble Exogenous Tumor Antigen, NY-ESO-1, by Distinct Human Dendritic Cell Populations,”Proc. Natl. Acad. Sci. USA 99, 10629-10634, (2002).
Dhodapkar, M. V. et al. “T Cells from the Tumor Microenvironment of Patients with Progressive Myeloma can Generate Strong, Tumor-Specific Cytolytic Responses to Autologous, Tumor-loaded Dendritic Cells,”Proc. Natl. Acad. Sci. 99,13009-13013, (2002).
Rafiq, K. et al. “Immune Complex-Mediated Antigen Presentation Induces Tumor Immunity,”J. Clin. Invest. 110, 71-79, (2002).
Gil-Torregrosa, B. C. et al., “Control of Cross-Presentation During Dendritic Cell Maturation,”Eur. J. Immunol. 34,398-407, (2004).
Rodriguez, A. et al., “Selective Transport of Internalized Antigens to the Cytosol for MHC Class I Presentation in Dendritic Cells”,Nat. Cell Biol. 1, 362-368, (1999).
Sedlik, C. et al., “A Critical Role for Syk Protein Tyrosine Kinase in Fc Receptor-Mediated Antigen Presentation and Induction of Dendritic Cell Maturation,”J. Immunol. 170, 846-852, (2003).
Akiyama, K. et al. “Targeting Apoptotic Tumor Cells to FcγR Provides Efficient and Versatile Vaccination Against Tumors by Dendritic Cells,”J. Immunol. 170,1641-1648, (2003).
Ravetch, J. V. “A Full Complement of Receptors in Immune Complex Diseases,”J. Clin. Invest. 110, 1759-1761, (2002).
Kalergis, A. M. et al. “Inducing Tumor Immunity Through the Selective Engagement of Activating Fcγ Receptors on Dendritic Cells,”J. Exp. Med. 195, 1653-1659, (2002).
Jonuleit, H. et al., “Pro-inflammatory Cytokines and Prostaglandins Induce Maturation of Potent Immunostimulatory Dendritic Cells Under Fetal Calk Serum-Free Conditions,”Eur. J. Immunol. 27, 3135-3142, (1997).
Sallusto, F., et al., “Efficient Presentation of Soluble Antigen by Cultured Human Dendritic Cells is Maintained by Granulocyte/Macrophage Colony-Stimulating Factor Plus Interleukin 4 and Downregulated by Tumor Necrosis Factor,”J. Exp. Med. 179,1109-1118, (1994).
Bave, U., et al., “FcγRIIa is Expressed on Natural IFN-α-Producing Cells (Plasmacytoid Dendritic Cells) and is Required for the IFN-α Production Induced by Apoptotic Cells Combined with Lupus IgG,”J. Immunol. 171, 3296-3302, (2003).
Schifferli, J. A. et al., “Physiological and Pathological Aspects of Circulating Immune Complexes,”Kidney Int. 35, 993-1003, (1989).
Mustafa, A.S., et al., “BCG Induced CD4+Cytotoxic T Cells From BCG Vaccinated Healthy Subjects: Relation Between Cytotoxicity and Suppression In Vitro,”Clin. Exp. Immunol., 69, 255-262, (1987).
Kaliński, P., et al. “Prostaglandin E2is a Selective Inducer of Interleukin-12 p40 (IL-12p40) Production and an Inhibitor of Bioactive IL-12p70 heterodimer,”Blood, 97, 3466-3469, (2001).
Heath, W. R. et al., “Cross-Presentation, Dendritic Cells, Tolerance and Immunity”,Annu. Rev. Immunol. 19, 47-64, (2001).
Wardemann, H., et al., “Predominant Autoantibody Production by Early Human B Cell Precursors,”Science, 301,1374-1377, (2003).
Li, X., et al. “A Novel Polymorphism in the Fcγ Receptor IIB (CD32B) Transmembrane Region Alters Receptor Signaling,”Arthritis Rheum. 48, 3242-3252, (2003).
Su, K. et al., “A Promoter Haplotype of the Immunoreceptor Tyrosine-Based Inhibitory Motif-Bearing FcγRIIb Alters Receptor Expression and Associates with Autoimmunity. I. Regulatory FCGR2B Polymorphisms and Their Association with Systemic Lupus Erythematosus,”J. Immunol. 172, 7186-7191, (2004).
Fukuy

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