Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound
Patent
1992-09-17
1994-01-11
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
In an organic compound
424 4, 424 71, 424 9, 514 64, 514836, 514946, 514492, A61K 4900, A61K 3128, A61K 3169
Patent
active
052778975
ABSTRACT:
The invention relates to compositions that comprise (1) lipophilic cationic organometallic complexes, particularly hexakis(2-methoxyisobutylisonitrile)technetium(I) complex, and (2) an agent that decreases the intramembrane potential of a living cell. Agents which decrease the intramembrane potential of a living cell include the lipophilic anions, especially tetraphenylborate anion. The invention also relates to methods in which the compositions are administered in vivo and in vitro when it is desirable to obtain enhanced cellular accumulation of lipophilic cationic organometallic complexes. The compositions and methods are useful for diagnosis and treatment, p
REFERENCES:
patent: 3873296 (1975-03-01), Ashmead et al.
patent: 4946683 (1990-08-01), Forssen
Piwnica-Worms, David et al., "Editorial: Noncardiac Applications of Hexakis-(alkylisonitrile) Technetium-99m Complexes", J. Nucl. Med. 31(7):1166-1167 (1990).
Piwnica-Worms, David et al., "Enhancement of Hexakis(methoxyisobutylisonitrile).sup.99m Tc (Tc-MIBI) Accumulation in Cultured Chick Embryo Myocardial Cells by Tetraphenylborate", Circulation 82(4):Suppl. III, No. 1931 (1990).
Ramsay, Rona R. et al., "Enhancement by Tetraphenylboron of the Interaction of the 1-Methyl-4-Phenylpyridinium Ion (MPP.sup.+) with Mitochondria", Biochem. Biophys. Res. Comm. 159(3):983-990 (1989).
Meerdink, Denis J. et al., "Comparison of Hypoxia and Ouabain Effects on the Myocardial Uptake Kinetics of Technetium-99m Hexakis 2-Methoxyisobutyl Isonitrile and Thallium-201", J. Nucl. Med. 30:1500-1506 (1989).
Melnik, Eugene et al., "Phloretin-Induced Changes in Ion Transport across Lipid Bilayer Membranes", J. Gen. Physiol. 69:243-257 (1977).
Neef, Cees et al., "Hepatic Uptake and Biliary Excretion of Organic Cations-II: The Influence of Ion Pair Formation", Biochem. Pharmacol. 33(24):3991-4002 (1984).
Chiu, Mary L. et al., "Effect of Mitochondrial and Plasma Membrane Potentials on Accumulation of Hexakis (2-Methoxyisobutylisonitrile)Technetium(I) in Cultured Mouse Fibroblasts", J. Nucl. Med. 31:1646-1653 (1990).
Chiu, Mary L. et al., "Monitoring Mitochondrial and Plasma Membrane Potentials in Cultured Cells with a New .sup.99m Tc-based Lipophilic Cation", J. Gen. Physiol. 94:41a (1989).
Flewelling, Ross F. et al., "Hydrophobic Ion Interactions with Membranes: Thermodynamic Analysis of Tetraphenylphosphonium Binding to Vesicles", Biophys. J. 49:531-540 (1986).
Sinusas, A. J. et al., "Correlation of Myocardial Uptake of Technetium-99m Methoxy-Isobutyl Isonitrile with Regional Flow during Coronary Occlusion and Reperfusion", J. Nucl. Med. 30:756 [Entry No. 115] (1989).
Altendorf, Karlheinz et al., "Accumulation of Lipid-Soluble Ions and of Rubidium as Indicators of the Electrical Potential in Membrane Vesicles of Escherichia coli", J. Biol. Chem. 250(4):1405-1412 (1975).
Bakeeva, L. E. et al., "Conversion of Biomembrane-Produced Energy into Electric Form", Biochim. et Biophys. Acta 216:13-21 (1970).
Cheng, Kang et al., "Measurement of Membrane Potentials (.psi.) of Erthrocytes and White Adipocytes by the Accumulation of Triphenylmethylphosphonium Cation", J. Membrane Biol. 56:191-201 (1980).
Kronauge James F.
Piwnica-Worms David R.
Brigham and Women's Hospital
Hollinden Gary C.
Hollrah Glennon H.
LandOfFree
In vivo enhancement of cellular accumulation of lipophilic catio does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with In vivo enhancement of cellular accumulation of lipophilic catio, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and In vivo enhancement of cellular accumulation of lipophilic catio will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1629435