In-vivo diagnostic method by means of near infrared radiation

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Diagnostic or test agent produces in vivo fluorescence

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C548S100000, C548S146000, C548S400000, C424S001110, C424S001650, C424S009100

Reexamination Certificate

active

06926885

ABSTRACT:
This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.

REFERENCES:
patent: 4945239 (1990-07-01), Wist et al.
patent: 5298379 (1994-03-01), Adin et al.
patent: 5880287 (1999-03-01), Dandliker et al.
patent: 6083485 (2000-07-01), Licha et al.
patent: 6329531 (2001-12-01), Turner et al.
patent: 6630570 (2003-10-01), Licha et al.
patent: 2001/0055567 (2001-12-01), Licha et al.
patent: 2003/0170179 (2003-09-01), Licha et al.
patent: 709463 (1968-07-01), None
patent: 2910760 (1980-04-01), None
patent: 3828360 (1990-02-01), None
patent: 3912046 (1990-03-01), None
patent: 4136769 (1993-05-01), None
patent: 4323368 (1995-01-01), None
patent: 8404665 (1984-12-01), None
patent: 8910758 (1989-11-01), None
patent: 9010219 (1990-09-01), None
patent: 9118006 (1991-11-01), None
patent: 9200748 (1992-01-01), None
Buttner et al, ‘Laser Mammographie mit NIR-Licht’, Gynakol Geburtshifliche Rundsch, vol. 33 (Suppl. 1), pp. 299-300, 1993.
Navarro et al, ‘Contast in diaphanography of the breast’, Am. Assoc. Phys. Med., vol. 15, No. 2, pp. 181-187, 1988.
Bonnett, “New photosensitisers for the photodynamic therapy of tumours,”SPIE,vol. 2078, pp. 1-17, 1994.
Benaron, “Optical Imaging reborn with technical advances,”Diagnostic Imaging,pp. 69-76, 1994.
Folli, “Antibody-Indocyanin Conjugates for Immunophotodetection of Human Squamous Cell Carcinoma in Nude Mice,”Cancer Research,vol. 54, pp. 2643-2649, 1994.
Mujumdar et al., “Cyanine Dye Labeling Reagents: Sulfoindocyanine Succinimidyl Esters,”Bioconjugate Chemistry,vol. 4, No. 2, pp. 105-111, 1993.
Terpetschnig et al., “Synthesis, spectral properties and photostabilities of symmetrical and unsymmetrical squaraines; a new class of fluorophores with long-wavelength excitation and emission,”Analytica Chimica Acta,vol. 282,pp. 633-641, 1993.
Terpetschnig et al., “An investigation of Squaraines as a New Class of Fluorophores with Long-Wavelength Excitation, and Emission,”Journal of Fluorescence,vol. 3, No. 3, p. 153, 1993.
Büttner et al., “Laser-Mammographie mit NIR-Licht,”Gynäkol Geburtshilfiche Rundsch,vol. 33 (Suppl 1), pp. 299-300, 1993.
Googe et al., “Intraoperative Fluorescein Angiography,”Ophthalmology,vol. 100, No. 8, pp. 1167-1170, 1993.
Henschen et al., “Determination of Plasma Volume and Total Blood Volume Using Indocyanine Green: A Short Review,”Journal of Medicine,vol. 24, No. 1, pp. 10-27, 1993.
Boyer et al., “Evaluation of Near Infrared Dyes as Labels for Immunoassays Utilizing Laser Diode Detection: Development of Near Infrared Dye Immunoassay (NIRDIA),”Analytical Letters,vol. 25, No. 3, pp. 415-418, 1992.
Lansdorp et al., “Single Laser Three Color Immunofluorescence Staining Procedures Based on Energy Transfer Between Phycoerythrin and Cyanine 5,”Cytometry,vol. 12, pp. 723-730, 1991.
Alveryd et al., “Lightscanning Versus Mammography for the Detection of Breast Cancer in Screening and Clinical Practice,”Cancer,vol. 65, No. 8 pp. 1671-1677, 1990.
Ernst et al., “Cyanine Dye Labeling Reagents for Sulfhydryl Groups,”Cytometry,vol. 10, pp. 3-10, 1989.
Satori et al., “Laser-Induced Autofluorescence of Human Arteries,”Circulation Research,vol. 63, No. 6, pp. 1053-1059, 1988.
Navarro et al., “Contrast in diaphanography of the breast,”Am. Assoc. Phys. Med.,vol. 15, No. 2, pp. 181-187, 1988.
Beuthan et al., “IR-Diaphanoscopy in Medicine,”Medical Optical Tomography: Functional Imaging and Monitoring,vol. 1S11, pp. 263-282, 1993.
Slominskii et al., “Tricarbocyanines with Hydrocarbon Rings in the Chromophore,”Ukrainskii Khimicheskii Zhumal,vol.40, No. 6, pp. 61-84, 1974.
Kuramoto, “The role of excited singlet molecular oxygen in the photodegradation of functional squarylium dyes,”JSDC,vol. 108, pp. 181-186, 1990.
Kuramoto et al., “Synthesis and Characterization of Deep-Coloured Squarylium Dyes for Laser Optical Recording Media,”Dyes and Pigments,vol. 11, pp. 21-35, 1989.
Bonnett, “New photosensitisers for the photodynamic therapy of tomours,”SPIE,vol. 2078, pp. 1-17, 1994.
Benaron, “Optical imaging reborn with technical advances,”Diagnostic Imaging,pp. 69-76, 1994.
Folli, “Antibody-Indocyanin Conjugates for Immunophotodetection of Human Squamous Cell Carcinoma in Nude Mice,”Cancer Research,vol. 54, pp. 2643-2649, 1994.
Terpetschnig et al., “An investigation of Squarines as a New Class of Fluorophores with Long-Wavelength Excitation and Emissionj,”Journal of Fluorescence,vol. 3, p. 153, 1993.
Googe et al., “Intraoperative Fluorescein Angiography,”Ophthalmology,vol. 100, No. 8, pp. 1167-1170, 1993.
Lansdorp et al., “Single Laser Three Color Immunofluorecence Staining Procedures Based on Energy Transfer Between Phycoerythrin and Cyanine 5,”Cytometry,vol. 12, pp. 723-730, 1991.
Ernst et al., “Cyanine Dye Labeling Reagents of Sulfhydryl Groups,”Cytometry,vol. 10, pp. 3-10, 1989.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

In-vivo diagnostic method by means of near infrared radiation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with In-vivo diagnostic method by means of near infrared radiation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and In-vivo diagnostic method by means of near infrared radiation will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3510561

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.