In vivo brain imaging agent and method for diagnosis of psychiat

Details In vivo brain imaging agent and method for diagnosis of psychiat In vivo brain imaging agent and method for diagnosis of psychiat

1990-11-16

1994-04-19

Stoll, Robert L.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

A61K 4902

Patent

active

053043677

ABSTRACT:
A composition useful as an imaging agent comprises a beta adrenergic receptor antagonist compound, preferably iodopindolol, to which is covalently attached an iodine radioisotope such as .sup.123 I or .sup.124 I. This composition is used in a method for radioimaging beta adrenergic receptors in a tissue, preferably brain. In particular, the method is useful with the radioimaging technique of single photon emission computed tomography (SPECT) or positron emission tomography (PET). The above composition, as well as a kit comprising a set of one or more standard radiographic images of beta adrenergic receptors, are also useful in methods for (1) diagnosing an alteration in beta adrenergic receptors in a tissue, particularly brain; (2) diagnosing suicidal depression in a subject; and (3) detecting the therapeutic normalization of beta adrenergic receptor expression in a subject.

REFERENCES:
patent: 4311685 (1982-01-01), Snyder
patent: 4970238 (1990-11-01), Louis et al.
Weinberger, D. R. et al., Adv. Neurol. 51:147-150 (1990).
Antoni, G. et al., Appl. Radiat. Isot. 40:561-564 (1989) (Int. J. Radiat. Appl. Instrum. Part A).
Wagner, H. N., Jr., In: Quantitative Receptor Autoradiography, Boast, C. A. et al., eds., Alan R. Liss, Inc., 1986, pp. 233-254).
Hughes, B. et al., Nuc. Med. Biol. 13:565-71 (1986).
Hughes, B. et al., J. Nucl. Med. 27:66-667 (1986).
Tondo, L. et al., J. Pharmacol. Exp. Ther. 235:1-1 (1985).
Conway, P. G. et al. J. Pharmacol. Exp. Ther. 241:755-62 (1987).
Rainbow, T. C. et al., J. Neurosci. Meth. 5:127-138 (1982).
Rainbow, T. C. et al. Proc. Natl. Acad. Sci. USA 81:1585-89 (1984).
Kuhar, M. J. In: Quantitative Receptor Autoradiography, Boast, C. A. et al., eds., Alan R. Liss, Inc., 1986, pp. 1-12.
Mann, J. J. et al., Arch. Gen. Psychiat. 43:954-959 (1986).
Biegon, A. et al., Brain Res. 442:199-203 (1988).
Garvey, H. L. et al. J. Pharmacol. Exp. Ther. 194:220-233 (1975).
Arendt, R. M. et al. Cardiology 71:307-314 (1984).
Arnett, C. D. et al. J. Neurochem. 44:835 (1985).
Arnett, C. D. et al., J. Nucl. Med. 27:1878 (1986).
Kinsey, B. et al. Abstract for Soc. Nucl. Medicine 38th Ann. Meeting, Jun. 11-14, (1991).
Tewson, T. J. et al. (abstract 7) and Kinsey, B. M. et al., abstract (source known).
Tewson, T. J. et al., Paper from 1986 Radio-pharmaceutical Chemistry Meeting, Boston, pp. 388-90.
Moretti-Rojas et al, "Serotonergic and Adrenergic Regulation . . . ," J. Biol. Chem, vol. 258, No. 20, Oct. 25, 1983, pp. 12499-12508.
Hughes et al, "Characterization of Beta-Adrenoreceptors . . . ", J. Nucl Med, vol. 27(5), 1986, pp. 660-667.

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