Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Attached to antibody or antibody fragment or immunoglobulin;...
Patent
1995-06-05
1999-10-12
Green, Lora M.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Attached to antibody or antibody fragment or immunoglobulin;...
424 157, 4241781, 4241791, 4241811, 4241831, A61K 39395, A61K 5100, A61K 5110
Patent
active
059651067
ABSTRACT:
A method for in-vivo targeting a functional moiety in a patient by administering a targeting moiety coupled to an affinity component, wherein the targeting moiety has affinity for binding sites in a target area, and administering a binding partner to the affinity component coupled to a functional moiety to localize the functional moiety in the target area. Preferably the targeting moiety is an antibody and the functional moiety is a radiometal when performing in vivo imaging or therapy. The affinity component may be a novel methotrexate analog. Preferably, the affinity component is thermo-stabilized.
REFERENCES:
patent: 4002532 (1977-01-01), Weltman et al.
patent: 4468469 (1984-08-01), Atkinson
patent: 4661347 (1987-04-01), Muller-Eberhard et al.
patent: 4762707 (1988-08-01), Jansen et al.
patent: 4975278 (1990-12-01), Senter et al.
H. Nygren et al., Journal of Immunological Methods, 85:87-95 (1985).
B. Birdsall et al., Biochemistry, 28:2297-2305, Easton, PA, USA, (1989).
M.V. Pimm et al., British Journal of Cancer, 61:508-513, (1990).
T.J. McCallister et al., FASEB Journal 2, 4:A690:Abstract No. 2284, Mar. 1988.
A.D. Broom et al., J. Med. Chem., 32:2-7, (1989).
J. Inglese et al., J. Med. Chem., 32:937-949 (1989).
R.B. Silverman et al., Medicinal Research Reviews, 4:3:415-447 (1984).
R.R. Rando et al., Methods in Enzymology, 46:28-41, (1977).
P. Blackburn et al., The Enzymes, xv:317-433 (1982).
F.S. Lee er al., Biochemistry, 28:225-230 (1989).
H.J. Hansen et al., Chemical Abstracts, 115:Abstract No. 205931u, 1991.
Appelman et al., Journal of Biological Chemistry, 263:21:10304-10313, 1988.
M. Pimm et al., British Journal of Cancer, 61:508-513 (1990).
T. McCallister et al., FASEB Journal 2, 4:Abstract No. 2284, 1988.
Neuberger MS, Williams GT, et al, (1984) Recombinant antibodies possessing novel effector functions. Nature 312:604-608.
Bredehorst Reinhard
Hawkins Gregory A.
Kim Chong-Ho
McCabe Richard P.
Pomato Nicholas
Gormley Mary E.
Green Lora M.
PerImmune Holdings, Inc.
LandOfFree
In vivo binding pair pretargeting does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with In vivo binding pair pretargeting, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and In vivo binding pair pretargeting will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-649287