Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Attached to antibody or antibody fragment or immunoglobulin;...
Patent
1995-05-30
1998-09-15
Green, Lora M.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Attached to antibody or antibody fragment or immunoglobulin;...
424 157, 4241781, 4241791, 4241811, 4241831, A61K 39395, A61K 5100, A61K 5110
Patent
active
058075348
ABSTRACT:
A method for in-vivo targeting a functional moiety in a patient by administering a targeting moiety coupled to an affinity component, wherein the targeting moiety has affinity for binding sites in a target area, and administering a binding partner to the affinity component coupled to a functional moiety to localize the functional moiety in the target area. Preferably the targeting moiety is an antibody and the functional moiety is a radiometal when performing in vivo imaging or therapy. The affinity component may be a novel methotrexate analog.
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Bredehorst Reinhard
Hawkins Gregory Alan
Kim Chong-Ho
McCabe Richard P.
Pomato Nicholas
Akzo Nobel N.V.
Gormley Mary E.
Green Lora M.
Musto Neal A.
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