In vivo assay for identification of antimicrobial agents

Details In vivo assay for identification of antimicrobial agents In vivo assay for identification of antimicrobial agents

2006-03-14

2006-03-14

Bugaisky, Gabriele (Department: 1656)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S007200, C435S007320, C435S007370, C435S018000, C435S029000, C435S032000

Reexamination Certificate

active

07011946

ABSTRACT:
The present invention provides novel in vivo assay systems and methods of using these assays systems to identify compounds that affect microbial cell division. The present invention further provides pharmaceutical compositions that have anti-microbial activity and methods of treating microbial infections.

REFERENCES:
Sarcina et al. Effects of tubulin assembly inhibitors on cell division in prokaryotes in vivo. 2000 FEMS microbiology letters, 191 (1) p25-9.
Ohashi et al. The lethal effect of a benzamide derivative, 3-methoxybenzamide, can be suppressed by mutations within a celll division gene, ftsZ, inBacillus subtilis. Feb. 1999 Journal of bacteriology, 181 (4) p1348-51.

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