Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – The nonhuman animal is a model for human disease
Patent
1997-09-26
2000-03-07
Campell, Bruce R.
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
The nonhuman animal is a model for human disease
800 21, 424 92, 424 931, A01K 6700, A61K 4800, C12N 1500
Patent
active
060342978
ABSTRACT:
Disclosed is a method for expressing hepatitis C virus in an in vivo, animal model. Viable, hepatitis C virus-infected, human hepatocytes are transplanted into a liver parenchyma of a scid/scid mouse host. The scid/scid mouse host is then maintained in a viable state, for up to five days or greater, whereby viable, morphologically intact human hepatocytes persist in the donor tissue and hepatitis C virus is replicated in the persisting human hepatocytes.
REFERENCES:
patent: 5434341 (1995-07-01), Outzen
patent: 5476996 (1995-12-01), Wilson et al.
patent: 5476997 (1995-12-01), Kaneshima et al.
patent: 5858328 (1999-01-01), Reisner
Proc. Natl. Acad. Sci. USA, vol. 92 pp. 4942-4946, May 1995 Medical Sciences Complete Reconstitution of Mouse Liver With Zenogeneic Hepatocytes Jonathan A. Rhim, Eric P. Sandgren, Richard D. Palmiter, Ralph L. Brinster.
The Journal of Infectious Diseases (1995), Hepatitis C Virus Viremia in SCID-BNX Mouse Chimera, pp. 25-30.
Jaffee, Bruce D., and Henry N. Claman, "Chronic Graft-versus-Host Disease (GVHD) as a Model for Scleroderma", Cellular Immunology, vol. 77, pp. 1-12 (1983).
Lerat, Herve et al., "Specific Detection of Hepatitis C Virus Minus Strand RNA in Hematopoietic Cells," J. Clin Invest., vol. 97, No. 3, pp. 845-851, Feb. 1996.
Vierling, John M. et al., "Hepatic Lesions in Murine Chronic Graft-Versus-Host Disease to Minor Histocompatibility Antigens, A Reproducible Model of Non-suppurative Destructive Cholangitis," Transplantation, vol. 48, No. 4, pp. 717-718, Oct. 1989.
Veirling et al. Xenografting of Human HCV-Infected Liver into Sever Combined Immunodeficiency (SCID) Mice. Hepatology, vol. 24, No. 4, Pt. 2, p. 218A, Oct. 1996.
Medical Virology, Fourth Edition, White et al., eds. Academic Press, pp. 447-448, 1994.
Stedman's Medical Dictionary, 26th edition, Spraycar, ed. Williams & Wilkins, p. 1300, 1995.
Campell Bruce R.
Cedars-Sinai Medical Center
Clark Deborah J. R.
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