Measuring and testing – Specimen stress or strain – or testing by stress or strain... – Specimen clamp – holder – or support
Patent
1997-10-01
1999-05-11
Noori, Max H.
Measuring and testing
Specimen stress or strain, or testing by stress or strain...
Specimen clamp, holder, or support
73 6441, G01N3/02;37/00
Patent
active
059029374
ABSTRACT:
An in vitro tissue testing system especially useful for testing blood/tissue interactions. The system includes a tissue holding frame which forms a chamber between two flat pieces of tissue with a spacer plate therebetween. The spacer plate includes a reservoir aperture bordered on both sides by the opposed tissue pieces, and a mechanism for depressing portions of the tissue pieces inwardly into the chamber to propel blood from one side of the chamber to the other. The flow created simulates actual blood flow in a host system. The reservoir aperture may be hourglass shaped with circular end portions and a middle blood passageway. The actuating mechanism may include pistons for alternating contact with the tissue within the confines of the opposite reservoir end portions, thus propelling blood from one end portion to the other. The pistons may be driven by a plurality of eccentric cams on shafts coupled to a common drive motor. The holding frame may include two outer plates for sandwiching the tissue pieces against the spacer plate, the outer pieces having openings corresponding to the reservoir end portions, and the pistons reciprocate through the openings into contact with the tissue.
REFERENCES:
patent: 4864865 (1989-09-01), Stoakley et al.
patent: 4986964 (1991-01-01), Carr, Jr. et al.
patent: 5289826 (1994-03-01), Kovacevic
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patent: 5777215 (1998-07-01), Calatzis et al.
U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, "Guidelines for Blood-Material Interactions", Devices and Technology Branch, Division of Heart and Vascular Diseases, National Heart, Lung, and Blood Institute, May. 1979.
Amrani David L.
Boggs Danial R.
Earles Keith A.
Baxter International Inc.
Cumberbatch Guy L.
Noori Max H.
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