In vitro test for dermal toxic properties

Details In vitro test for dermal toxic properties In vitro test for dermal toxic properties

1989-02-24

1991-10-01

Johnston, Jill

Chemistry: analytical and immunological testing

Process or composition for determination of physical state...

Surface area, porosity, imperfection, or alteration

73 643, 2103216, 422 56, 422 58, 422101, 436164, 436530, G01N 1300, G01N 2129

Patent

active

050533401

ABSTRACT:
A membrane support, reagent and method determines, in vitro, skin irritation properties of individual compounds and/or mixtures is disclosed. The material to be tested is applied directly to the membrane support. The material may penetrate the membrane and diffuse into the reagent and cause a response, for example, the production of a precipitate. The test material may also alter or destroy the membrane and/or disrupt covalently linked dye molecules attached to the membrane and diffuse into the reagent to produce an additional or alternate response--for example, color. The sum of these two responses is proportional to the deleterious response elicited by the material on the human skin.

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