In vitro test for dermal corrosive properties

Chemistry: analytical and immunological testing – Process or composition for determination of physical state... – Surface area – porosity – imperfection – or alteration

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436 6, 436 8, 436 63, 436161, 436164, 436171, 436173, 436530, 422 53, 422 56, 422 58, 422101, 73 6447, G01N 1300, G01N 2129

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active

054118883

ABSTRACT:
Methods for determining the corrosivity of a substance to human skin or membrane are disclosed. In one approach, corrosivity is evaluated by measuring the time required for the test substance to transit a biobarrier that mimics human skin or membranes or the time required to cause a component of such biobarrier to break down and transit the membrane. The invention also envisions alternative approaches which involve series of layers of dyes and corrosive-resistant materials coated onto microspheres or test strips. Use of these methods provides a rapid determination of the corrosivity of test materials.

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