In vitro production of haploid germ cells

Details In vitro production of haploid germ cells In vitro production of haploid germ cells

2005-03-29

2005-03-29

Afremova, Vera (Department: 1651)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of co-culturing cells

C435S382000, C435S378000, C435S383000, C435S366000, C435S352000

Reexamination Certificate

active

06872569

ABSTRACT:
The present invention relates to a method of in vitro spermatogenesis involving Sertoli cells and diploid germ cells from a testis of a male mammal to yield differentiated haploid spermatids. The present invention also relates to spermatids produced by the method described above, where the spermatids are haploid. The present invention also involves a method of overcoming male infertility in mammals involving the use of the haploid round spermatids produced by the in vitro spermatogenesis method of the present invention. The present invention also relates to isolated haploid spermatids.

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