In vitro process for detecting endotoxin in a biological fluid

Details In vitro process for detecting endotoxin in a biological fluid In vitro process for detecting endotoxin in a biological fluid

1974-12-27

1976-03-16

Wolk, Morris O.

Chemistry: physical processes

Physical processes

Crystallization

1951035R, 210 24, C12K 100, G01N 3106, G01N 3316

Patent

active

039443914

ABSTRACT:
An in vitro process for detecting the presence of endotoxin in a biological fluid such as a parenteral fluid, whole blood, and the like, wherein amebocyte lysate from the hemolymph of the horseshoe crab, Limulus polyphemus, is intimately contacted with and incubated in the presence of a synthetic plastic polymer capable of adsorbing endotoxin which has previously been contacted with the biological fluid. The presence or absence of a gelation reaction in the amebocyte lysate is then observed. The presence of a gelation reaction determines the presence of endotoxin in the biological fluid.

REFERENCES:
patent: 3770631 (1973-11-01), Fekete
patent: 3794584 (1974-02-01), Kunin
Chemical Abstracts, 72:64863c (1970).
Chemical Abstracts, 78:13536q (1973).

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