In vitro micro-organs

Details In vitro micro-organs In vitro micro-organs

1994-11-16

1999-03-30

Prats, Francisco

Chemistry: molecular biology and microbiology

Differentiated tissue or organ other than blood, per se, or...

435347, 435373, 435374, A01N 102

Patent

active

058887202

ABSTRACT:
A micro-organ culture is provided that includes a nutrient medium in a culture vessel, the vessel containing an oxygen concentration not substantially greater than that in the atmosphere and a population of non-fetal animal cells disposed in the nutrient medium for greater than 24 hours. The population of cells is derived from an organ which has an in vivo structure including an epithelial tissue and an adjacent stroma. The population of cells consists of a plurality of cell types, the population including both stromal and epithelial tissues of the in vivo tissue structure. Furthermore, the population of cells has a volume described by a first, second and third dimension such that at least one dimension is no greater than 0.45 mm. The stromal and epithelial tissues are preserved in the nutrient medium devoid of an internally disposed synthetic support structure or sandwich structure.

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