Combinatorial chemistry technology: method – library – apparatus – Method of screening a library – By measuring the ability to specifically bind a target...
Reexamination Certificate
2001-11-14
2010-12-28
Steele, Amber D. (Department: 1639)
Combinatorial chemistry technology: method, library, apparatus
Method of screening a library
By measuring the ability to specifically bind a target...
C506S006000, C506S014000, C506S016000, C506S018000, C506S026000, C435S320100, C435S325000, C530S387100
Reexamination Certificate
active
07858559
ABSTRACT:
The present invention relates to a high efficiency method of expressing immunoglobulin molecules in eukaryotic cells. The invention is further drawn to a method of producing immunoglobulin heavy and light chain libraries, particularly using the trimolecular recombination method, for expression in eukaryotic cells. The invention further provides methods of selecting and screening for antigen-specific immunoglobulin molecules, and antigen-specific fragments thereof. The invention also provides kits for producing, screening and selecting antigen-specific immunoglobulin molecules. Finally, the invention provides immunoglobulin molecules, and antigen-specific fragments thereof, produced by the methods provided herein.
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Smith Ernest S.
Zauderer Maurice
Steele Amber D.
Sterne Kessler Goldstein & Fox P.L.L.C.
University of Rochester
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