In-vitro methods for identifying compositions which are agonists

Details In-vitro methods for identifying compositions which are agonists In-vitro methods for identifying compositions which are agonists

1989-04-18

1992-08-04

Saunders, David A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

435948, C12Q 102

Patent

active

051358492

ABSTRACT:
The present invention provides general protocols by which a substance may be identified and characterized as an androgen agonist and/or an androgen antagonist. The described protocols are in-vitro methods which utilize androgen dependent cells in culture and a medium comprising an inhibitor endogenous to the sera of humans and animals which is able to prevent the proliferation of these cultured cells in-vitro. The methodology is rapid, reproducible, and accurate; and provides the major advantage of being able to test large numbers of unevaluated substances for their androgen agonistic and/or antagonistic properties as primary properties or secondary side-effects.

REFERENCES:
patent: 4859585 (1989-08-01), Sonnenschein et al.
Horoscewicz et al., Biol. Abstr., 76, Abstr. No. 42757, 1983.
Noguchi et al., Cancer Research, 47, 263-268, 1987.
Stanley et al., Cell, 10, 35-44, 1977.

Affiliated with

Also associated with

Rating

In-vitro methods for identifying compositions which are agonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with In-vitro methods for identifying compositions which are agonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and In-vitro methods for identifying compositions which are agonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-777711