Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1993-03-25
1997-03-04
Nucker, Christine M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
435 724, 435 23, 435219, C12Q 170, G01N 3353, G01N 33555, G01N 33567
Patent
active
056078315
ABSTRACT:
Calpain has been identified as a component of the biochemical pathway in programmed cell death. Calpain inhibitors are effective in preventing the progression to cell death and can restore cell function. T lymphocytes from HIV infected individuals undergo T cell receptor-triggered programmed cell death which can be treated by calpain inhibitors and immune function can be restored in affected cells. Methods for diagnosing cell populations or individuals susceptible to programmed cell death and for monitoring therapeutic effectiveness are provided.
REFERENCES:
Schwartz, R., "Autoimmunity and autoimmune diseases", in Fundamental Immunology, Paul, ed., Raven Press, New York, 1993, pp. 1033-1098.
Murachi et al., "A Quantitative Distribution Study on Calpain and Calpastatin in Rat Tissues and Cells", Biochem. Int. 2: 651 (1981).
Hanada et al., "Characterization of the Three New Analogs of E-64 and Their Therapeutic Application", Proteinase Inhibitors: Medical and Biological Aspects, Katunuma, ed., Springer-Verlag, Tokyo, pp. 25-36 (1983).
Amamoto et al., "Effect of E-64, a Thiol Protease Inhibitor, on Antibody Formation in Mice", Biochem. Biophys. Res. Comm. 118: 117 (1984).
Adachi et al., "Distribution and Expression of Calpastatin in Human Hematopoietic System Cells", Biol. Chem. 369:223-227 (May, 1988).
Murachi, "Intracellular Regulatory System Involving Calpain & Calpastatin" Biochem. Int. 18: 263-294 (1989).
Mercep et al., "The Cell Cycle Block and Lysis of an Activated T Cell Hybridoma are Distinct Processes with Different Ca.sup.2+ Requirements and Sensitivity to Cyclosporine A", J. Immunol. 142: 4085 (1989).
Ito et al., "The Thiol Proteinase Inhibitors Improve the Abnormal Rapid Down-Regulation of Protein Kinase C and the Impaired Natural Killer Cell Activity in (Chediak-Higashi Syndrome) Beige Mouse", Biochem. Biophy. Res. Comm. 160:433-440 (Apr., 1989).
Ucker et al., "Activation-Driven T Cell Death", J. Immunol. 143: 3461 (1989).
Clerici et al., "Detection of Three Distinct Patterns of T Helper Cell Dysfunction in Asymptomatic, Human Immunodeficiency Virus-Seropositive Patients", J. Clin. Invest. 84: 1892 (1989).
Arends et al., "Apoptosis, The Role of the Endonuclease", Am. J. Pathol. 136:593 (1990).
Odaka et al., "T Cell Receptor-Mediated DNA Fragmentation and Cell Death in T Cell Hybridomas", J. Immunol. 144: 2096 (1990).
Shi et al., "Activation-induced Cell Death in T Cell Hybridomas is Due to Apoptosis", J. Immunol. 144: 3326 (1990) (erratum at 145: 3945).
Webb et al., "Extrathymic Tolerance of Mature T Cells: Clonal Elimination as a Consequence of Immunity", Cell 63:1249 (1990).
Zacharchuk et al., "Programmed T Lymphocyte Death", J. Immunol. 145: 4037 (1990).
Piedimonte et al., "Protease Activation During HIV Infection in a CD4-Positive Cell Line", AIDS Res. Hum. Retrovir. 6: 251-260 (1990).
Wang, "Developing Selective Inhibitors of Calpain", Trends Pharmacol. Sci. 11: 139-142 (1990).
Petteway et al., "The Chronically Infected Cell as a Target for the Treatment of HIV Infection and AIDS", TiPS 12: 28-34 (Jan. 1991).
Guy et al., "A Specific Inhibitor of Cystein Proteases Impairs a Vif-Dependent Modification of Human Immunodeficiency Virus Type 1 Env Protein", J. Virol. 65: 1325-1331 (Mar., 1991).
Croall et al., "Calcium-Activated Neutral Protease (Calpain) System: Structure, Function, and Regulation", Physiol. Rev. 71: 813-847 (1991).
Lee et al., "Inhibition of Proteolysis Protects Hippocampal Neurons from Ischemia", Proc. Natl. Acad. Sci. 88: 7233 (1991).
Sellins et al., "Cytotoxic T Lymphocytes Induce Different Types of DNA Damage in Target Cells of Different Origins", J. Immunol. 147:795 (1991).
Lucey et al., "Human Immunodeficiency Virus Infection in the US Air Force: Seroconversions, Clinical Staging, and Assessment of a T Helper Cell Functional Assay to Predict Change in CD4+ T Cell Counts", J. Infect. Dis. 164:631 (1991).
Ameisen et al., "Cell Dysfunction and Depletion in AIDS: the Programmed Cell Death Hypothesis", Immunol. Today 12: 102-104 (1991).
Shenoy et al., "Inhibition of the Calpain-Mediated Proteolysis of Protein Kinase C Enhances Lytic Activity of Human NK Cells", Cell. Immunol. 138: 24-34 (1991).
Groux et al., "Activation-Induced Death by Apoptosis in CD4+ T Cells form Human Immunodeficiency Virus-Infected Asymptomatic Individuals", J. Exp. Med. 174: 331-340 (Feb., 1992).
Gadrielescu, "An Integrative Approach to the Proteolytic Control of the Cell-Mediated Cytotoxicity" Roum. Arch. Microbiol. Immunol. 51: 33 (Jan.-Jun., 1992).
Meyaard et al., "Programmed Death of T Cells in HIV-1 Infection," Science 257: 217-219 (Jul., 1992).
Bruno et al., "Inhibitors of Proteases Prevent Endonucleolysis Accompanying Apoptotic Death of HL-60 Leukemic Cells and Normal Thymocytes," Leukemia 6:1113-1120 (Nov., 1992).
Saido et al., "Positive Regulation of .mu.-Calpain Action by Polyphosphoinositides" J. Biol. Chem. 267: 24585-24590 (Dec., 1992).
Ameisen, "Programmed Cell Death and AIDS: from Hypothesis to Experiment", Immunol. Today 13: 388-392 (1992).
Green et al., "Activation-induced Apoptosis in Lymphoid Systems", Semin. Immunol. 4: 379 (1992).
Gavrieli et al., "Identification of Programmed Cell Death in situ via Specific Labeling of Nuclear DNA Fragmentation", J. Cell Biol. 119: 493 (1992).
Clerici Mario
Henkart Pierre
Sarin Apurva
Shearer Gene M.
Nucker Christine M.
Parkin Jeffrey S.
The United States of America as represented by the Department of
LandOfFree
In vitro methods for assessing the susceptibility of HIV-1-infec does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with In vitro methods for assessing the susceptibility of HIV-1-infec, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and In vitro methods for assessing the susceptibility of HIV-1-infec will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2145379