Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1992-12-15
1996-08-20
Scheiner, Toni R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 71, 435 792, 436518, 436811, C12Q 168, G01N 3353, G01N 33543
Patent
active
055478417
ABSTRACT:
The invention relates to an in vitro method of screening for drugs, potentially useful for treatment of Alzheimer's Disease. The method involves contacting a drug with a host transformed with a DNA construct which contains at least the DNA coding for human A4-amyloid peptide and overexpresses the peptide and then detecting the prevention of production or increased degradation of the A4-peptide due to the drug.
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Marotta Charles A.
Zain Sayeeda
Duffy Patricia A.
Scheiner Toni R.
The McLean Hospital Corporation
University of Rochester
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