Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1992-08-26
1999-02-02
Mosher, Mary E.
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
4352351, 4353201, 935 32, C12N 1500, C12N 1586, C12N 701
Patent
active
058663835
ABSTRACT:
In a preferred embodiment of the invention, methods are provided for the production of viral vectors from large viral genomes (greater than 50 kbp) that incorporate nucleic acid insertions by direct in vitro ligation. In another preferred embodiment of this invention, viral vectors are provided from large viral genomes. These viral vectors accommodate nucleic acid inserts by direct in vitro ligation and facilitate the expression of foreign protein in eukaryotic cell systems.
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Merchlinsky Michael J.
Moss Bernard
Mosher Mary E.
The United States of America as represented by the Department of
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