In vitro human monoclonal IgG rheumatoid factor autoantibody

Details In vitro human monoclonal IgG rheumatoid factor autoantibody In vitro human monoclonal IgG rheumatoid factor autoantibody

1987-03-30

1991-07-23

Kepplinger, Esther L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

530387, 530808, 43524027, 4351722, 436548, 935100, 935110, G01N 33577, C07K 1528

Patent

active

050343165

ABSTRACT:
Human monoclonal IgG RF is provided in stable supply from immortalized cells. The IgG RF can be used for diagnosis and study of rheumatoid arthritis. In addition, anti-idiotype antibodies can be provided for use in diagnosis and therapy.
The cell line hRF-1 was deposited at the A.T.C.C. on January 16, 1991 and given accession No. ATCC 10645.

REFERENCES:
Steinitz, M. et al., "In Vitro-produced Monoclonal Rheumatoid Factor: Purification, Radiolabeling, and Possible Applications". Cell. Immunol. 69(2): 205-14, 1982, as cited in Chemical Abstracts, accession no. CA97(3); 21886m.
Pope, R. M. et al. "The Molecular Basis of Self-Association of Antibodies to IgG (Rheumatoid Factors) in Rheumatoid Arthritis,"Proc. Nat. Acad. Sci.71(2): 517-521, Feb. 1974.

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