In vitro HIV integrase inhibitors

Details In vitro HIV integrase inhibitors In vitro HIV integrase inhibitors

1996-10-24

1998-06-02

Knode, Marian C.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435121, 435911, 548539, C12N 112, C12N 100, C12P 1710, C07D70700

Patent

active

057598428

ABSTRACT:
Natural products such as equisetin and derivatives are described. These compounds are useful in the inhibition of HIV integrase.

REFERENCES:
patent: 5352800 (1994-10-01), Bills et al.
LaFemina et al., Antimicrobial Agents & Chemotherapy, vol. 39(2), pp. 320-324 (1995), "Inhibition of human immunodeficiency virus integrase by bis-catechols".
Cushman et al., J. Med. Chem., vol. 38 (1995), pp. 443-452, "Cosalane analogues with enhanced potencies as inhibitors of HIV-1 protease and integrase".
Mazumder et al., Biochemistry, vol. 34 (1995), pp. 15111-15122, "Effects of tyrphostins, protein kinase inhibitors, on human immunodeficiency virus type 1 integrase".
Mazumder et al., J. Med. Chem., vol. 39 (1996), pp. 2472-2481, "Antiretroviral agents as inhibitors of both human immunodeficiency virus type 1 integrase and protease".
Mazumder et al., Molecular Pharmacology, vol. 49 (1996), pp. 621-628, "Effects of nucleotide analogues on human immunodeficiency virus type 1 integrase".
Kusumoto et al., C.A. 120(19):238888s, "A comparative study on the inhibitory effects of flavonoids and alkaloids on reverse transcriptases of different retroviruses".
Mazumder et al., AIDS Research and Human Retroviruses, vol. 11(1), pp. 115-125 (1995), "Inhibition of human immunodeficiency virus type 1 integrase by a hydrophobic cation . . . ".
Mazumder et al., Proc. Nat'l Acad. Sci. USA, vol. 91, pp. 5771-5775 (1994), "Inhibition of human immunodeficiency virus type 1 integrase by 3'-azido-3'-deoxythymidylate".
Carteau et al., Biochemical Pharm., vol. 47(10), pp. 1821-1826 (1994), "Inhibition of the in vitro integration of moloney murine leukemia virus DNA by the DNA minor groove binder netropsin".
Fesen et al., Proc. Nat'l Acad. Sci. USA, vol. 90 (1993), pp. 2399-2403, "Inhibitors of human immunodeficiency virus integrase".
Farnet et al., Proc. Nat'l Acad. Sci. USA, vol. 93 (1996), pp. 9742-9747, "Differential inhibition of HIV-1 preintegration complexes and purified integrase protein by small molecules".
Lutzke et al., Proc. Nat'l Acad. Sci. USA, vol. 92 (1995), pp. 11456-11460, "Identification of a hexapeptide inhibitor of the human immunodeficiency virus integrase protein by using a combinatorial chemical library".
Ojwang et al., Antimicrobial Agents & Chemotherapy, vol. 39(11), pp. 2426-2435 (1995), "T30177, an oligonucleotide stabilized by an intramolecular guanosine octet, is a potent inhibitor . . . ".
Eich et al., J. Med. Chem., vol. 39 (1996), pp. 86-95, "(-)-Arctigenin as a lead structure for inhibitors of human immunodeficiency virus type-1 integrase".
Konig et al., J. of Bioenergetics & Biomembranes, vol. 25(5), pp. 537-545 (1993), "Effects of equisetin on rat liver mitochondria: evidence for inhibition of substrate anion carriers of the inner membrane".
Philipps et al., J. Am. Chem. Soc., vol. 111 (1989), pp. 8223-8231, "Characterization of the fusarium toxin equisetin: the use of phenylboronates in structure assignment".
Turos et al., J. Am. Chem. Soc., vol. 111 (1989), pp. 8231-8236, "Total synthesis of the fusarium toxin equisetin: proof of the stereochemical relationship of the tetramate and terpenoid sectors".
Hazuda et al., Nucleic Acids Research, vol. 22(6), pp. 1121-1122 (1994), "A novel assay for the DNA strand-transfer reaction of HIV-1 integrase".
Burke et al., J. Med. Chem., vol. 38 (1995), pp. 4171-4178, "Hydroxylated aromatic inhibitors of HIV-1 integrase".
Hazuda et al., J. of Virology, vol. 71(1), pp.807-811 (1997), "Equivalent inhibition of half-site and full-site retroviral strand transfer reactions by structurally diverse compounds".
Fesen et al., Biochemical Pharma., vol. 48(3), pp. 595-608 (1994), "Inhibition of HIV-1 integrase by flavones, caffeic acid phenthyl ester (cape) and related compounds".
Carteau et al., Archives of Biochemistry & Biophysics, vol. 305(2), pp. 606-610 (1993), "Inhibitory effect of the polyanionic drug suramin on the in vitro HIV DNA integration reaction".
Robinson, Jr., et al., Proc. Nat'l Acad. Sci. USA, vol. 93 (1996), pp. 6326-6331, "Inhibitors of HIV-1 replication that inhibit HIV integrase".
PRNewswire, Sep. 17, 1996, "Aronex reports results for lead anti-HIV integrase inhibitor compound".

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