Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Primate cell – per se
Patent
1995-06-07
1998-12-22
Elliott, George C.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Primate cell, per se
435325, 435366, 435383, 435384, C12N 506, C12N 508, C12N 502
Patent
active
058518320
ABSTRACT:
A method for the in vitro proliferation and differentiation of neural stem cells and stem cell progeny comprising the steps of (a) isolating the cells from a mammal, (b) exposing the cells to a culture medium containing a growth factor, (c) inducing the cells to proliferate, and (d) inducing the cells to differentiate is provided.
REFERENCES:
patent: 4753635 (1988-06-01), Sagen et al.
patent: 4980174 (1990-12-01), Sagen et al.
patent: 5082670 (1992-01-01), Gage
patent: 5175103 (1992-12-01), Lee et al.
patent: 5411883 (1995-05-01), Boss et al.
patent: 5612211 (1997-03-01), Wilson et al.
Almazan et al., "Epidermal Growth and Bovine Growth Hormone Stimulate Differentiation and Myelination of Brain Cell Aggregates in Culture," Developmental Brain Research, 21:257-264 (1985).
Anchan et al., "Trophic Factors Influence Proliferation of Germinal Neuroepithelial Cells of the Retina, " J. Cell Biol., 109:58a, Abstract No. 308 (1989).
Anchan et al., "EGF and TGF-.alpha. Stimulate Retinal Neuroepithelial Cell Proliferation in Vitro," Neuron, 6(6):923-936 (1991).
Bayer et al., "Neuron production in the Hippocampus and olfactory bulb of the adult rat Brain: addition or replacement?", Annals NY. Acad. Sci. 457:163-172 (1985).
Bjorklund et al., "Neural Grafting in Animal Models of Neurodegenerative Diseases," Ann. New York Acad. Sci., 457:53-81 (1985).
Bouvier et al., "Basic Fibroblast Growth Factor (bFGF) Promotes the Survival and Proliferation of Mesencephalic Neuronal Precursors in Vitro," Society for Neuroscience Abstracts, vol. 18, Abstract No.: 403.7 (1992).
Boyles et al., "Accumulation of Apolipoproteins in the Regenerating and Remyelinating Mammalian Peripheral Nerve," J. Biol. Chem., 265(29):17805-17815 (1990).
Calof et al., "Analysis of Neurogenesis in a Mammalian Neuroepithelium: Proliferation and Differentiation of an Olfactory Neuron Precursor in Vitro," Neuron, 3:115-127 (1989).
Cattaneo et al., "Identifying and Manipulating neuronal stem cells," TINS, 14(8): 338-340 (1991).
Cattaneo et al., "Proliferation and differentiation of neuronal stem cells regulated by nerve growth factor," Nature, 347:762-765 (1990).
Cepko "Immortalization of neural cells via retrovirus-mediated oncogene transduction," Ann. Rev. Neurosci., 12:47-65 (1989).
Deloulme et al., "Establishment of Pure Neuronal Cultures From Fetal Rat Spinal Cord and Proliferation of the Neuronal Precursor Cells in the Presence of Fibroblast Growth Factor," Journal of Neuroscience Research, 29:499-509 (1991).
Dunnett et al., "Dopamine-rich transplants in experimental Parkinsonism," TINS, 266-270 (Jul. 1983).
Emerich et al., "Behavioral Effects of Neural Transplantation,"Cell Transplantation, 1:1-27 (1992).
Faaland et al., "Rapid uptake of tyrphostin into A431 human epidermoid cells is followed by delayed inhibition of epidermal growth factor (EGF)-stimulated EGF receptor tyrosine kinase activity", Mol. Cell Biol. 11(5):2697-2703 (1991).
Ferrari et al., "Basic Fibroblast Growth Factor Promotes the Survival and Development of Mesencephalic Neurons in Culture," Developmental Biology, 133:140-147 (1989).
Frederickson et al., "Immortal Neuroepithelial Precursor Cell Lines," Society for Neuroscience Abstracts, 13:182 Abstract No. 55.6 (1987).
Frederiksen et al., "Proliferation and differentiation of rat neuroepithelial precursor cells in vivo," The Journal of Neuroscience 8(4):1144-1151 (1988).
Frederiksen et al., "Immortalization of precursor cells from the mammalian CNS," Neuron, 1:439-448 (1988).
Freed et al., "Transplantation of human fetal dopamine cells for Parkinson's disease," Arch. Neurol., 47:505-512 (1990).
Freshney, "Culture of Animal cells--A Manual of Basic Techniques", Alan R. Liss, Inc., N.Y. pp. 190-195.
Freshney, "Culture of Animal Cells--A Manual of Basic Techniques," Alan R. Liss, Inc., N.Y., Chapter 11, pp. 137-153 (1987).
Geller et al., "A defective HSV-1 vector expresses Escherichia coli .beta.-galactosidase in cultured peripheral neurons," Science, 241:1667-1669 (1988).
Gensburger et al., "Brain basic fibroblast growth factor stimulates the proliferation of rat neuronal precursor cells in vitro," FEBS Letts, 217(1):1-5 (1987).
Godfraind et al., "In Vivo Analysis of Glial Cell Phenotypes during a Viral Demyelinating Disease in Mice," Journal of Cell Biology 109(5):2405-2416.
Groves et al., "Repair of demyelinated lesions by transplantation of purified O-2A progenitor cells," Nature, 362:453 (1993).
Hall et al., "Stem cells: the generation and maintenance of cellular diversity," Development, 106:619-633 (1989).
Hoffman et al., "Transplantation of a polymer-encapsulated cell line genetically engineered to release NGF," Exp. Neurol. 122:100-106 (1993).
Hunter et al., "Growth factor responses of enriched bipotential glial progenitors," Developmental Brain Research, 54(2):235-248 (1990).
Hunter et al., "Growth factor responses of enriched bipotential glial progenitors," Biol. Abstr. 90:7, Abstract No. 78581 (1990).
Hurtig et al., "Postmortem analysis of adrenal-medulla-to-caudate autograft in a patient with Parkinson's disease," Annals of Neurology, 25(6):607-614 (1989).
Jiao et al., "Intracerebral transplants of primary muscle cells: a potential `platform` for transgene expression in the brain," Brain Research, 575:143 (1992).
Kaplan, "Neurogenesis in the 3-month-old rat visual cortex," J. Comp. Neurol., 195:323 (1981).
Kawaja et al., "Somatic gene transfer of nerve growth factor promotes the survival of axotomized septal neurons and the regeneration of their axons in adult rats," J. Neurosci., 12(7)2849 (1992).
Korr et al., "Autoradiographic investigation of glial proliferation in the bran of adult mice," J. Comp. Neurol., 150(2):169-176 (1973).
Lendahl et al., "CNS stem cells express a new class of intermediate filament protein," Cell, 60 585-595 (1990).
Lin et al., "GDNF: A Glial Cell Line-Derived Neurotrophic Factor Midbrain Dopaminergic Neurons," Science, 260:1130 (1993).
Lindvall et al., "Grafts of fetal dopamine dnurons survive and improve motor function in Parkinson's disease," Science, 247:574-577 (1990).
Lois et al., "Migration of neuroblasts from the lateral ventricle to the olfactory bulb in the adult mammalian CNS", Society for Neuroscience Abstracts, vol. 19, Abstract #361.6 (1993).
Luskin et al., Rate and pattern of migration of olfactory bulb interneurons generated postnatally in the subventricular zone, Society for Neuroscience Abstracts, vol. 19, Abstract #361.9 (1993).
Masters et al., "Insulin-like growth factor I (IGF-I) receptors and IGF-I action in oligodendrocytes from rat brains," Regulatory Peptides, 33(2):117-131 (1991).
Masters et al., "Insulin-like growth factor I (IGF-I) receptors and IGF-I action in oligodendrocytes from rat brains," Biol. Abstr. 93:3, Abstract No. 31828 (1992).
McKinnon et al., "FGF modulates the PDGF-driven pathway of oligodendrocyte development," Neuron 5:603-614 (1990).
Morrison et al., "Trophic stimulation of cultured neurons from neonatal rat brain by epidermal growth factor," Science, 238:72-75 (1987).
Metcalf, "The hemopoietic regulators--an embarrassmetn of riches", Bioassays 14(12):799-805 (1992).
Morshead et al., "Neural stem cells are located in the subependymal region of the adult mammalian forebrain", Society for Neuroscience Abstracts, vol. 19, Abstract#360.7 (1993).
Morshead et al., "Postmitotic Death is the Fate of Constitutively Proliferating Cells in the Subependymal Layer of the Adult Mouse Brain," The Journal of Neuroscience, 12(1):249-256 (1992).
Murphy et al., "Fibroblast growth factor stimulates the Proliferation and Differentiation of Neural Precursor Cells In Vitro," Jour. of Neuroscience Research, 25(4):463-475 (1990).
Mytilineou et al., "Epidermal Growth Factor-Induced Survival and Proliferation of Neuronal Precursor Cells from Embryonic Rat Mesencephalon," Neuroscience Letters, 135:62-66 (1992).
Nakafuku et al., "Epidermal growth factor and transforming growth factor-.alpha. can induce neuronal differentiation of rat pheochromocytoma PC12 cells under particular culture conditions" FEBS Letts, 315(3):227-232 (1993).
Notter et al., "Neuro
Baetge E. Edward
Hammang Joseph P.
Reynolds Brent
Weiss Samuel
Elliott George C.
Neurospheres, Ltd.
Railey II Johnny F.
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