In vitro generation of human dendritic cells

Details In vitro generation of human dendritic cells In vitro generation of human dendritic cells

1996-04-25

1999-12-21

Lankford, Jr., Leon B.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435347, 435373, 435326, C12N 500

Patent

active

060048077

ABSTRACT:
A method is provided for generating human dendritic cells in vitro by treating CD34.sup.+ cells with tumor necrosis factor-.alpha. and interleukin-3 or with GM-CSF. The invention also includes cellular compositions of dendritic cells produced by this method. Dendritic cells of the invention can be used widely as components in many diagnostic and therapeutic systems, including improved mixed lymphocyte reactions for assaying tissue rejection, adoptive immunotherapy of cancer, adoptive immunotherapy of HIV and other viral infections, and SCID-hu mice for human antibody production.

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