Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2011-06-28
2011-06-28
Ketter, Jim (Department: 1636)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S180000, C435S375000
Reexamination Certificate
active
07968287
ABSTRACT:
The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; and (b) sorting the genetic elements which express the gene product having the desired activity; wherein at least one step is under microfluidic control. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention.
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Beebe et
Ahn Keunho
Bibette Jerome
Griffiths Andrew
Link Darren R.
Weitz David
Brown Rudnick LLP
Ketter Jim
Medical Research Council Harvard University
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